Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effect of hypothyroidism on G protein-coupled receptor kinase 2 expressionlevels in rat liver, lung, and heart
Autore:
Penela, P; Barradas, M; Alvarez-Dolado, M; Munoz, A; Mayor, F;
Indirizzi:
Univ Autonoma Madrid, Ctr Biol Mol Severo Ochoa, Dept Biol Mol, E-28049 Madrid, Spain Univ Autonoma Madrid Madrid Spain E-28049 iol Mol, E-28049 Madrid, Spain Univ Autonoma Madrid, CSIC, Inst Invest Biomed, E-28049 Madrid, Spain UnivAutonoma Madrid Madrid Spain E-28049 Biomed, E-28049 Madrid, Spain
Titolo Testata:
ENDOCRINOLOGY
fascicolo: 3, volume: 142, anno: 2001,
pagine: 987 - 991
SICI:
0013-7227(200103)142:3<987:EOHOGP>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-ADRENERGIC RECEPTORS; FAILING HUMAN HEART; GENE-TARGETED MICE; ADENYLATE-CYCLASE; BETA(2)-ADRENERGIC RECEPTOR; CARDIOVASCULAR FUNCTION; BRAIN DEVELOPMENT; THYROID STATUS; DESENSITIZATION; RESPONSIVENESS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Mayor, F Univ Autonoma Madrid, Ctr Biol Mol, E-28049 Madrid, Spain Univ Autonoma Madrid Madrid Spain E-28049 E-28049 Madrid, Spain
Citazione:
P. Penela et al., "Effect of hypothyroidism on G protein-coupled receptor kinase 2 expressionlevels in rat liver, lung, and heart", ENDOCRINOL, 142(3), 2001, pp. 987-991

Abstract

GRK2 is a member of the G protein-coupled receptor kinase family that phosphorylates the activated form of beta -adrenergic and other G protein-coupled receptors and plays an important role in their desensitization and modulation. Alterations in thyroid hormone levels have been reported to lead to important changes in adrenergic receptor responsiveness and signaling in a variety of tissues. In this context, we have explored the effects of experimental hypothyroidism on GRK2 protein levels in rat heart, lung, and liver using a specific antibody. Hypothyroid animals show significant up-regulation(similar or equal to 50% increase compared with controls) in GRK2 levels in heart and lung at 60 days after birth, whereas a 50% reduction is detected in the liver at this stage. These alterations are selective, as P-adrenergic receptors or other G protein-coupled receptor regulatory proteins, such as G protein-coupled receptor kinase 5 or beta -arrestin-1, display a different pattern of expression changes in the hypothyroid animals. The reported changes in GRK2 levels and in the receptor/kinase ratio predict alterations in adrenergic receptor desensitization and signal transduction efficacyconsistent with those observed in thyroid disorders, thus suggesting a relevant role for the modulation of GRK2 expression in this physiopathologicalcondition.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 00:21:51