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Titolo:
GATA factors differentially activate multiple gonadal promoters through conserved GATA regulatory elements
Autore:
Tremblay, JJ; Viger, RS;
Indirizzi:
CHU Laval, Res Ctr, Ontogeny & Reprod Res Unit, Quebec City, PQ G1V 4G2, Canada CHU Laval Quebec City PQ Canada G1V 4G2 , Quebec City, PQ G1V 4G2, Canada Univ Laval, Dept Obstet & Gynecol, Ctr Res Biol Reprod, Quebec City, PQ G1V 4G2, Canada Univ Laval Quebec City PQ Canada G1V 4G2 Quebec City, PQ G1V 4G2, Canada
Titolo Testata:
ENDOCRINOLOGY
fascicolo: 3, volume: 142, anno: 2001,
pagine: 977 - 986
SICI:
0013-7227(200103)142:3<977:GFDAMG>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
STEROIDOGENIC FACTOR-I; MULLERIAN-INHIBITING SUBSTANCE; TRANSCRIPTION FACTOR GATA-1; ORPHAN NUCLEAR RECEPTOR; ALPHA-SUBUNIT GENE; HELIX-LOOP-HELIX; HEART TUBE FORMATION; BINDING-PROTEIN; SERTOLI CELLS; PITUITARY GONADOTROPE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
72
Recensione:
Indirizzi per estratti:
Indirizzo: Viger, RS CHU Laval, Res Ctr, Ontogeny & Reprod Res Unit, T1-49,2705 Laurier Blvd, Quebec City, PQ G1V 4G2, Canada CHU Laval T1-49,2705 Laurier Blvd Quebec City PQ Canada G1V 4G2
Citazione:
J.J. Tremblay e R.S. Viger, "GATA factors differentially activate multiple gonadal promoters through conserved GATA regulatory elements", ENDOCRINOL, 142(3), 2001, pp. 977-986

Abstract

The GATA factors are a group of transcriptional regulators that play essential roles in cell differentiation, organ morphogenesis, and tissue-specific gene expression during development. The six vertebrate GATA factors are expressed in a broad spectrum of tissues, including the hemopoietic system, heart, gut, brain, placenta, pituitary, and gonads. Interestingly, GATA-like DNA-binding proteins are found in the gonads of several species, ranging from lower invertebrates to humans, thus supporting an evolutionary conserved and crucial role for these factors in gonadal development and function. Indeed, GATA factors are expressed from the onset of gonadal development and are later found in multiple cell lineages of both the testis and ovary. We now report that GATA-4 differentially activates transcription of several genes expressed in the gonads that encode either steroidogenic enzymes (steroidogenic acute regulatory protein and aromatase), hormones (inhibin cu and Mullerian inhibiting substance) and a transcription factor (SF-1) known to be essential for gonadal development and function. Thus, our results identify GATA-4 as an important regulator of gonadal gene transcription where its specificity of action is mediated through synergistic interactions with other transcription factors such as SF-1.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 22:25:07