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Titolo:
An activation-independent role of transcription factors in insulator function
Autore:
Fourel, G; Boscheron, C; Revardel, E; Lebrun, E; Hu, YF; Simmen, KC; Muller, K; Li, R; Mermod, N; Gilson, E;
Indirizzi:
Ecole Normale Super Lyon, CNRS, UMR5665, ENSL,Lab Biol Mol & Cellulaire, F-69364 Lyon, France Ecole Normale Super Lyon Lyon France F-69364 laire, F-69364 Lyon, France Univ Virginia, Dept Biochem & Mol Genet, Hlth Sci Ctr, Charlottesville, VA22908 USA Univ Virginia Charlottesville VA USA 22908 , Charlottesville, VA22908 USA Ecole Polytech Fed Lausanne, IGC, DC, Ctr Biotechnol UNIL,Lab Biotechnol Mol UNIL, CH-1015 Lausanne, Switzerland Ecole Polytech Fed Lausanne Lausanne Switzerland CH-1015 ne, Switzerland
Titolo Testata:
EMBO REPORTS
fascicolo: 2, volume: 2, anno: 2001,
pagine: 124 - 132
SICI:
1469-221X(200102)2:2<124:AAROTF>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITION-EFFECT VARIEGATION; SACCHAROMYCES-CEREVISIAE; YEAST; BOUNDARIES; DOMAIN; HETEROCHROMATIN; REPLICATION; DROSOPHILA; TELOMERE; PROMOTER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Fourel, G Ecole Normale Super Lyon, CNRS, UMR5665, ENSL,Lab Biol Mol & Cellulaire, F-69364 Lyon, France Ecole Normale Super Lyon Lyon France F-69364 9364 Lyon, France
Citazione:
G. Fourel et al., "An activation-independent role of transcription factors in insulator function", EMBO REP, 2(2), 2001, pp. 124-132

Abstract

Chromatin insulators are defined as transcriptionally neutral elements that prevent negative or positive influence from extending across chromatin toa promoter. Here we show that yeast subtelomeric anti-silencing regions behave as boundaries to telomere-driven silencing and also allow discontinuous propagation of silent chromatin. These two facets of insulator activity, boundary and silencing discontinuity, can be recapitulated by tethering various transcription activation domains to tandem sites on DNA. Importantly, we show that these insulator activities do not involve direct transcriptional activation of the reporter promoter. These findings predict that certainpromoters behave as insulators and partition genomes in functionally independent domains.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 17:07:51