Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Maximal post-prandial triglyceride increase reflects post-prandial hypertriglyceridaemia and is associated with the insulin resistance syndrome
Autore:
Karamanos, BG; Thanopoulou, AC; Roussi-Penesi, DP;
Indirizzi:
Univ Athens, Hippokrat Hosp, Ctr Diabet, Dept Med 2, Athens 11527, Greece Univ Athens Athens Greece 11527 Diabet, Dept Med 2, Athens 11527, Greece
Titolo Testata:
DIABETIC MEDICINE
fascicolo: 1, volume: 18, anno: 2001,
pagine: 32 - 39
SICI:
0742-3071(200101)18:1<32:MPTIRP>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
HOMEOSTASIS MODEL ASSESSMENT; PLASMA-LIPOPROTEIN CHANGES; CORONARY HEART-DISEASE; MIDDLE-AGED SUBJECTS; POSTPRANDIAL LIPEMIA; FASTING HYPERTRIGLYCERIDEMIA; DENSITY-LIPOPROTEIN; FAT; GLUCOSE; MEN;
Keywords:
post-prandial hypertriglyceridaemia; insulin resistance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Karamanos, BG Univ Athens, Hippokrat Hosp, Ctr Diabet, Dept Med 2, 114 VasSofias Ave, Athens 11527, Greece Univ Athens 114 Vas Sofias Ave Athens Greece 11527 , Greece
Citazione:
B.G. Karamanos et al., "Maximal post-prandial triglyceride increase reflects post-prandial hypertriglyceridaemia and is associated with the insulin resistance syndrome", DIABET MED, 18(1), 2001, pp. 32-39

Abstract

Aims To assess the value of maximal post-prandial triglyceride increase after a high fat, low carbohydrate (CHO) test meal, as index of post-prandialhypertriglyceridaemia and its relation with insulin resistance. Methods Fifty non-diabetic subjects, 22 male and 28 female, aged 52.1 +/- 4.5 and 56.9 +/- 3.8 years, were studied. Glucose, insulin and triglycerides were measured fasting and 1, 2, 3 and 4 h after a meal consisting of 40 gfat, 19 g protein and 10 g CHO. Insulin resistance was calculated according to the HOMA model. Results The maximal triglyceride increment occurred during the 4th hour. Its absolute value (Delta -TG) and the per cent increase over the fasting value (PTI), were considered appropriate for the evaluation of the post-prandial triglyceride response. Both Delta -TG and PTI were strongly correlated with triglycerides incremental area in males and females, r = 0.797 and r =0.700, P < 0.01 and r = 0.805 and r = 0.774, P < 0.001, respectively, and thus they can be used as indices of the post-prandial triglyceride response. No correlation was found between fasting triglyceride and triglyceride incremental area or Delta -TG. Thus, post-prandial hypertriglyceridaemia can occur irrespectively of the fasting triglyceride concentrations. A weak correlation was found between PTI and insulin resistance in females, r = 0.384, r < 0.05, but not in males, r = 0.224, P > 0.05. However further analysisby quartiles of PTI showed similar insulin resistance levels in the first three quartiles and a significant increase in the 4th, both for males and females, 4th vs. 3rd quartile 7.4 +/- 3.6 vs. 2.2 +/- 0.7 and 6.4 +/- 2.4 vs. 2.2 +/- 0.6, respectively. The 4th quartile corresponds to a PTI greater than or equal to 80%. Conclusions PTI after the high fat, low CHO test meal used, consistently reflects post-prandial hypertriglyceridaemia, is easily measured and it is not predicted by fasting triglycerides. A PTI greater than or equal to 80% is associated with a significant increase of insulin resistance, and might therefore be considered the cut-off point for an abnormal post-prandial hypertriglyceridaemic response, at least in relation with insulin resistance. Such response could be added to the abnormalities of the insulin resistance syndrome, as an independent parameter.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 14:53:53