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Titolo:
Expression and regulation of chicken fibroblast growth factor homologous factor (FHF)-4 during craniofacial morphogenesis
Autore:
Munoz-Sanjuan, I; Cooper, MK; Beachy, PA; Fallon, JF; Nathans, J;
Indirizzi:
Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 urosci, Baltimore, MD 21205 USA Univ Wisconsin, Dept Mol Biol & Genet, Madison, WI USA Univ Wisconsin Madison WI USA in, Dept Mol Biol & Genet, Madison, WI USA Univ Wisconsin, Dept Neurol, Madison, WI USA Univ Wisconsin Madison WI USA iv Wisconsin, Dept Neurol, Madison, WI USA Univ Wisconsin, Dept Anat, Madison, WI USA Univ Wisconsin Madison WI USAUniv Wisconsin, Dept Anat, Madison, WI USA Johns Hopkins Univ, Sch Med, Dept Ophthalmol, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 halmol, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Howard Hughes Med Inst, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 d Inst, Baltimore, MD 21205 USA
Titolo Testata:
DEVELOPMENTAL DYNAMICS
fascicolo: 3, volume: 220, anno: 2001,
pagine: 238 - 245
SICI:
1058-8388(200103)220:3<238:EAROCF>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR-BETA TRANSCRIPTS; RETINOIC-ACID; FACIAL PRIMORDIA; SONIC HEDGEHOG; NERVOUS-SYSTEM; NEURAL CREST; FACE; OUTGROWTH; INHIBITION; PATTERNS;
Keywords:
craniofacial development; talpid(2); retinoic acid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Nathans, J Johns Hopkins Univ, Sch Med, Dept Neurosci, 805 PCTB,725 N Wolfe St, Baltimore, MD 21205 USA Johns Hopkins Univ 805 PCTB,725 N Wolfe St Baltimore MD USA 21205
Citazione:
I. Munoz-Sanjuan et al., "Expression and regulation of chicken fibroblast growth factor homologous factor (FHF)-4 during craniofacial morphogenesis", DEV DYNAM, 220(3), 2001, pp. 238-245

Abstract

Fibroblast growth factor homologous factors (FHFs) have been implicated inlimb and nervous system development. In this paper we describe the expression of the cFHF-4 gene during chicken craniofacial development. cFHF-4 is expressed in the mesenchyme of the frontonasal process, and in the mesenchyme and ectoderm of the mandibular processes. The expression of cFHF-4 and other genes implicated in facial patterning have been analyzed in talpid(2) embryos or in the presence of exogenous retinoic acid. Talpid(2) mutants show abnormal patterns of gene expression, including up-regulation of cFHF-4 in the developing face, which correlate with defects in cartilage formation. By contrast, expression of cFHF-4 in the developing face is strongly downregulated by teratogenic doses of all-trans retinoic acid in a dose-dependent manner. Low levels of retinoic acid that produce distal upper beak truncations do not affect cShh, c-Patched-1, or c-Bmp-2 expression in the face, but downregulate cFHF-4 in the frontonasal process. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 23:23:52