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Titolo:
Retinoid X receptor and its partners in the nuclear receptor family
Autore:
Rastinejad, F;
Indirizzi:
Univ Virginia, Sch Med, Dept Pharmacol, Xray Crystallog Lab, Charlottesville, VA 22908 USA Univ Virginia Charlottesville VA USA 22908 Charlottesville, VA 22908 USA Univ Virginia, Sch Med, Dept Biochem & Mol Genet, Charlottesville, VA 22908 USA Univ Virginia Charlottesville VA USA 22908 Charlottesville, VA 22908 USA
Titolo Testata:
CURRENT OPINION IN STRUCTURAL BIOLOGY
fascicolo: 1, volume: 11, anno: 2001,
pagine: 33 - 38
SICI:
0959-440X(200102)11:1<33:RXRAIP>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
DNA-BINDING DOMAINS; DIRECT REPEATS; THYROID-HORMONE; COOPERATIVE BINDING; RESPONSE ELEMENTS; COMPLEX-FORMATION; ORPHAN RECEPTORS; HIGH-AFFINITY; ACID; RXR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Rastinejad, F Univ Virginia, Sch Med, Dept Pharmacol, Xray Crystallog Lab,Charlottesville, VA 22908 USA Univ Virginia Charlottesville VA USA 22908 le, VA 22908 USA
Citazione:
F. Rastinejad, "Retinoid X receptor and its partners in the nuclear receptor family", CURR OP STR, 11(1), 2001, pp. 33-38

Abstract

Retinoid X receptor (RXR) and its dimerization partners in the nuclear receptor family recognize DNA response elements in which two AGGTCA binding sites are arranged in tandem. Target site selection by these complexes requires the spacing between the binding sites to act as the identity element. With the recent determination of three-dimensional structures of several different DNA-binding complexes of RXR, together with studies of protein conformational changes, it is clear how the interactions of RXR with its partnersare precisely tuned to match the spacing between their DNA binding sites.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:44:49