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Titolo:
Non-genomic actions of aldosterone: role in hypertension
Autore:
Funder, JW;
Indirizzi:
Baker Med Res Inst, Melbourne, Vic 8008, Australia Baker Med Res Inst Melbourne Vic Australia 8008 urne, Vic 8008, Australia
Titolo Testata:
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
fascicolo: 2, volume: 10, anno: 2001,
pagine: 227 - 230
SICI:
1062-4821(200103)10:2<227:NAOARI>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULAR SMOOTH-MUSCLE; MINERALOCORTICOID RECEPTORS; GLUCOCORTICOID RECEPTOR; CELLS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Funder, JW Baker Med Res Inst, POB 6492,St Kilda Rd Cent, Melbourne, Vic 8008, Australia Baker Med Res Inst POB 6492,St Kilda Rd Cent Melbourne Vic Australia 8008
Citazione:
J.W. Funder, "Non-genomic actions of aldosterone: role in hypertension", CURR OP NEP, 10(2), 2001, pp. 227-230

Abstract

There is universal acceptance of the existence of rapid, nongenomic effects of aldosterone, although their physiological relevance and potential importance in hypertension are not yet clear. What has emerged over the year under review is that at least some of such rapid non-genomic effects of aldosterone may be mediated by the activation of the classical intracellular mineralocorticoid receptor, rather than a putative membrane receptor. The post-receptor mechanisms of rapid aldosterone action appear variously to involve protein kinase C, calcium, cyclic adenosine 3', 5'-monophosphate and inositol 1, 4, 5-triphosphate, with downstream effects on a variety of ion pumps and channels. Curr Opin Nephrol Hypertens 10:227-230. (C) 2001 LippincottWilliams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/12/18 alle ore 23:55:48