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Titolo:
Novel therapies for anti-neutrophil cytoplasmic antibody-associated vasculitis
Autore:
Tervaert, JWC; Stegeman, CA; Kallenberg, CGM;
Indirizzi:
Univ Hosp Maastricht, Dept Clin & Expt Immunol, NL-6202 AZ Maastricht, Netherlands Univ Hosp Maastricht Maastricht Netherlands NL-6202 AZ icht, Netherlands
Titolo Testata:
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
fascicolo: 2, volume: 10, anno: 2001,
pagine: 211 - 217
SICI:
1062-4821(200103)10:2<211:NTFACA>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
WEGENERS-GRANULOMATOSIS; SYSTEMIC VASCULITIS; RENAL INVOLVEMENT; NECROTIZING GLOMERULONEPHRITIS; TRIMETHOPRIM-SULFAMETHOXAZOLE; INTRAVENOUS IMMUNOGLOBULIN; MICROSCOPIC POLYANGIITIS; PLASMA-EXCHANGE; METHOTREXATE; DISEASE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Tervaert, JWC Univ Hosp Maastricht, Dept Clin & Expt Immunol, POB 5800, NL-6202 AZ Maastricht, Netherlands Univ Hosp Maastricht POB 5800 Maastricht Netherlands NL-6202 AZ
Citazione:
J.W.C. Tervaert et al., "Novel therapies for anti-neutrophil cytoplasmic antibody-associated vasculitis", CURR OP NEP, 10(2), 2001, pp. 211-217

Abstract

High-dose corticosteroids in combination with cytotoxic drugs are universally accepted as the initial approach in vasculitides that are associated with anti-neutrophil cytoplasmic antibodies. Cyclophosphamide is the most effective cytotoxic drug and is used in more severe cases. Because cyclophosphamide has more severe short- and long-term side-effects than methotrexate, methotrexate is used in less severe cases. New prospects for the treatment of vasculitis include novel immunosuppressive agents (e,g. mycophenolate, 15-deoxyspergualin, and leflunomide), sequential chemotherapy (e.g. cyclophosphamide followed by azathioprine or cyclophosphamide followed by methotrexate), intravenous immunoglobulin, tumour necrosis factor-a directed therapy, antilymphocyte directed therapy (e.g, antithymocyte globulin or anti CD52/anti CD4 antibodies), anti-adhesion molecule directed therapy (e.g. anti-CD18 or intercellular adhesion molecule-1 antisense) or immunoablation usinghigh-dose cytotoxic medication with or without stem cell rescue. Curr OpinNephrol Hypertens 10:211-217. (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 01:17:09