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Titolo:
Radiation-induced chromatid breaks and deficient DNA repair in cancer predisposition
Autore:
Parshad, R; Sanford, KK;
Indirizzi:
Howard Univ, Coll Med, Dept Pathol, Washington, DC 20059 USA Howard Univ Washington DC USA 20059 Dept Pathol, Washington, DC 20059 USA NCI, Cellular & Mol Biol Lab, NIH, Bethesda, MD 20892 USA NCI Bethesda MDUSA 20892 lar & Mol Biol Lab, NIH, Bethesda, MD 20892 USA
Titolo Testata:
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
fascicolo: 2, volume: 37, anno: 2001,
pagine: 87 - 96
SICI:
1040-8428(200102)37:2<87:RCBADD>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOUBLE-STRAND BREAKS; ATAXIA-TELANGIECTASIA CELLS; LI-FRAUMENI-SYNDROME; PHASE X-IRRADIATION; G2 CHROMOSOMAL RADIOSENSITIVITY; PERIPHERAL-BLOOD LYMPHOCYTES; HUMAN-TUMOR-CELLS; XERODERMA-PIGMENTOSUM; SUSCEPTIBILITY GENE; FLUORESCENT LIGHT;
Keywords:
chromatid breaks; DNA double-strand breaks; X-irradiation; DNA repair; cancer predisposition;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
88
Recensione:
Indirizzi per estratti:
Indirizzo: Parshad, R Howard Univ, Coll Med, Dept Pathol, 520 West St, Washington, DC20059 USA Howard Univ 520 West St Washington DC USA 20059 n, DC 20059 USA
Citazione:
R. Parshad e K.K. Sanford, "Radiation-induced chromatid breaks and deficient DNA repair in cancer predisposition", CR R ONC H, 37(2), 2001, pp. 87-96

Abstract

Deficient repair of DNA double-strand breaks, resulting in an abnormally high frequency of chromatid breaks after G(2) exposure of cells to radiation, appears to be associated with cancer predisposition. Unrepaired DNA strand breaks contribute to genomic instability. Unrepaired chromatid breaks representing DNA strand breaks can result in chromosome deletions, translocations and gene amplifications seen in human cancers. This cytogenetic response of cells to radiation may be useful as a marker of cancer susceptibility and in identifying individuals at risk of developing cancer in cancer families. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 07:04:40