Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Aetiopathogenesis and pathophysiology of bulimia nervosa - Biological bases and implications for treatment
Autore:
Brambilla, F;
Indirizzi:
Osped S Raffaele, Dipartimento Sci Neuropsiche, Ist Sci, I-20127 Milan, Italy Osped S Raffaele Milan Italy I-20127 iche, Ist Sci, I-20127 Milan, Italy
Titolo Testata:
CNS DRUGS
fascicolo: 2, volume: 15, anno: 2001,
pagine: 119 - 136
SICI:
1172-7047(2001)15:2<119:AAPOBN>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSESSIVE-COMPULSIVE DISORDER; CORTICOTROPIN-RELEASING-FACTOR; TERM WEIGHT RESTORATION; SERUM LEPTIN LEVELS; ANOREXIA-NERVOSA; EATING DISORDERS; CEREBROSPINAL-FLUID; SEROTONIN UPTAKE; BETA-ENDORPHIN; CHOLECYSTOKININ SECRETION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
166
Recensione:
Indirizzi per estratti:
Indirizzo: Brambilla, F Osped S Raffaele, Dipartimento Sci Neuropsiche, Ist Sci, Via Prinetti 29, I-20127 Milan, Italy Osped S Raffaele Via Prinetti 29 Milan Italy I-20127 , Italy
Citazione:
F. Brambilla, "Aetiopathogenesis and pathophysiology of bulimia nervosa - Biological bases and implications for treatment", CNS DRUGS, 15(2), 2001, pp. 119-136

Abstract

Bulimia nervosa is an eating disorder characterised by recurrent episodes of binge eating and associated efforts to purge the ingested calories through self-induced vomiting, laxative or diuretic abuse, fasting or intensive exercise. The aetiopathogenesis and pathophysiology of the disorder are currently unclear. Biological bases have been proposed repeatedly, based on several lines of evidence: hunger, satiety and food choice are regulated by neurotransmitters and neuropeptides, and impairment of eating habits may be related to alterations in the secretion of these chemicals; genetic studiessuggest that these neurotransmitter systems are dysfunctional in individuals with bulimia nervosa; and the frequent comorbidity of bulimia nervosa with major depressive and obsessive-compulsive disorders, conditions in whichmultiple alterations of brain biochemical functions have been demonstrated. Data in the literature suggest that levels of noradrenaline (norepinephrine) and serotonin (5-hydroxytryptamine; 5-MT) are lower in individuals with bulimia nervosa than in healthy controls. Levels of dopamine are similar to, or lower than, those in controls. After remission of the disorder, noradrenergic function returns to that seen in controls, whereas dopaminergic andserotonergic function rebound to levels higher than in controls. Among theneuropeptides, alterations in the levels of neuropeptide Y, peptide YY, beta -endorphin, corticotrophin-releasing hormone, somatostatin, cholecystokinin and vasopressin have been found in the symptomatic phase of bulimia nervosa, with a return to levels seen in controls after remission. Pharmacological treatment of bulimia nervosa that is directed at correction of the neurochemical alterations observed is difficult because of the complexity of the impairments. However, such treatment is necessary and shouldbe continued long after symptomatic remission to ensure reinstitution of cerebral biochemical homeostasis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 08:56:02