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Titolo:
Intravenous administration of magnesium sulfate in acute stroke: A randomized double-blind study
Autore:
Lampl, Y; Gilad, R; Geva, D; Eshel, Y; Sadeh, M;
Indirizzi:
Edith Wolfson Med Ctr, Dept Neurol, IL-58100 Holon, Israel Edith Wolfson Med Ctr Holon Israel IL-58100 urol, IL-58100 Holon, Israel Edith Wolfson Med Ctr, Dept Biostat, IL-58100 Holon, Israel Edith Wolfson Med Ctr Holon Israel IL-58100 stat, IL-58100 Holon, Israel Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 ac Med, IL-69978 Tel Aviv, Israel
Titolo Testata:
CLINICAL NEUROPHARMACOLOGY
fascicolo: 1, volume: 24, anno: 2001,
pagine: 11 - 15
SICI:
0362-5664(200101/02)24:1<11:IAOMSI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL INFARCTION; BLOOD-FLOW; TRIAL; RAT; CLASSIFICATION; PREECLAMPSIA; NEURONS; DAMAGE; BRAIN; SLICE;
Keywords:
magnesium sulfate; stroke; neuroprotection;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Lampl, Y Edith Wolfson Med Ctr, Dept Neurol, IL-58100 Holon, Israel Edith Wolfson Med Ctr Holon Israel IL-58100 58100 Holon, Israel
Citazione:
Y. Lampl et al., "Intravenous administration of magnesium sulfate in acute stroke: A randomized double-blind study", CLIN NEUROP, 24(1), 2001, pp. 11-15

Abstract

A randomized, placebo-controlled, double-blind study was performed as a pilot study to examine the benefit of the administration of magnesium sulfategiven intravenously as a protective substance during the first 24 hours following a stroke. Patients who had cortical infarction in the middle cerebral artery territory with moderate to severe neurologic deficits lasting formore than 15 minutes with onset less than 24 hours were included. The patients were treated with magnesium sulfate or placebo for 5 days and examinedby a blinded investigator. Patients had follow-up for 30 days. The primaryefficacy variable was the proportion of patients reaching mild to moderateneurologic deficit on the Orgogozo scale (80 points) and relative functional independence on the Barthel index (60 points). Orgogozo scale and Mathewscale values were obtained on admission and days 2, 4, 8, and 30 after stroke. Barthel activities of daily living index and Rankin disability score were obtained on day 30. Forty-one patients (22 given treatment and 19 givenplacebo) demonstrated significant beneficial effects on the Orgogozo scale(84 +/- 11 vs. 64 +/- 10, p < 0.0001) and (83 +/- 14 vs. 70 +/- 15, p < 0.009), respectively. At the end of 1-month follow-up, the Barthel ADL index was nonsignificantly higher and the Rankin disability score was marginally significantly lower in the magnesium-treated group (84 +/- 26 vs. 71.8 +/- 26, p < 0.143) than in control subjects (2.3 +/- 1.1 vs. 3 +/- 1.3, p < 0.077). Intravenous magnesium sulfate had significant positive effect on the outcome in patients with acute stroke. Further studies on a larger scale areneeded to confirm these findings.

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Documento generato il 25/01/20 alle ore 09:19:27