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Titolo:
Alpha-fetoprotein microheterogeneity: a potential biochemical marker for Down's syndrome
Autore:
Yamamoto, R; Azuma, M; Wakui, Y; Kishida, T; Yamada, H; Okuyama, K; Sagawa, T; Shimizu, K; Satomura, S; Fujimoto, S;
Indirizzi:
Hokkaido Univ, Sch Med, Dept Obstet & Gynecol, Kita Ku, Sapporo, Hokkaido 0608638, Japan Hokkaido Univ Sapporo Hokkaido Japan 0608638 oro, Hokkaido 0608638, Japan Walo Pure Chem Ind Ltd, Osaka Res Labs, Amagasaki, Hyogo, Japan Walo Pure Chem Ind Ltd Amagasaki Hyogo Japan bs, Amagasaki, Hyogo, Japan
Titolo Testata:
CLINICA CHIMICA ACTA
fascicolo: 1-2, volume: 304, anno: 2001,
pagine: 137 - 141
SICI:
0009-8981(200102)304:1-2<137:AMAPBM>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
LECTIN AFFINITY ELECTROPHORESIS; SCREENING MARKERS; TRISOMY-21; HCG;
Keywords:
alpha-fetoprotein; biochemical marker; carbohydrate structure; Down's syndrome; Lens culinaris agglutinin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Yamamoto, R Hokkaido Univ, Sch Med, Dept Obstet & Gynecol, Kita Ku, Kita 15,Nishi 7, Sapporo, Hokkaido 0608638, Japan Hokkaido Univ Kita 15,Nishi 7 Sapporo Hokkaido Japan 0608638 n
Citazione:
R. Yamamoto et al., "Alpha-fetoprotein microheterogeneity: a potential biochemical marker for Down's syndrome", CLIN CHIM A, 304(1-2), 2001, pp. 137-141

Abstract

Our purpose was to examine the utility of analyzing alpha-fetoprotein (AFP) microheterogeneity assessed by lectin affinity in Down's syndrome (DS) screening. Maternal sera and amniotic fluids were collected from 18 women whowere carrying DS fetuses and 70 unaffected pregnancies around 16 weeks of gestation. The percentages of AFP which reacted with Le,ls culinaris agglutinin (AFP-L2,3) were determined by lectin affinity electrophoresis. AFP-L2.3 levels were significantly increased (P<0.0001) in both maternal serum andamniotic fluid from DS-affected versus unaffected pregnancies. The fractional areas under the receiver operating characteristic curves were 0.835 and0.700 (P=0.106) for AFP-L3 and AFP MoM (multiples of the median) in maternal serum. No correlation was found between AFP-L3 and AFP MoM in maternal serum (r=0.006). Our data suggest that the measurement of AFP-L3 in maternalserum is a potential biochemical marker for DS. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 12:17:19