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Titolo:
Oxidation of LDL enhances the cholesteryl ester transfer protein (CETP)-mediated cholesteryl ester transfer rate to HDL, bringing on a diminished nettransfer of cholesteryl ester from HDL to oxidized LDL
Autore:
Castilho, LN; Oliveira, HCF; Cazita, PM; de Oliveira, AC; Sesso, A; Quintao, ECR;
Indirizzi:
Univ Sao Paulo, Sch Med, Lipid Lab LIM10, Sao Paulo, Brazil Univ Sao Paulo Sao Paulo Brazil Med, Lipid Lab LIM10, Sao Paulo, Brazil State Univ Campinas, Fac Med Sci, Dept Clin Pathol, Sao Paulo, Brazil State Univ Campinas Sao Paulo Brazil ept Clin Pathol, Sao Paulo, Brazil State Univ Campinas, Inst Biol, Dept Physiol & Biophys, Sao Paulo, Brazil State Univ Campinas Sao Paulo Brazil ysiol & Biophys, Sao Paulo, Brazil State Univ Campinas, Dept Nutr, Sao Paulo, Brazil State Univ Campinas SaoPaulo Brazil inas, Dept Nutr, Sao Paulo, Brazil Univ Sao Paulo, Sch Med, Dept Pathol, Sao Paulo, Brazil Univ Sao Paulo Sao Paulo Brazil Sch Med, Dept Pathol, Sao Paulo, Brazil
Titolo Testata:
CLINICA CHIMICA ACTA
fascicolo: 1-2, volume: 304, anno: 2001,
pagine: 99 - 106
SICI:
0009-8981(200102)304:1-2<99:OOLETC>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; LIPID TRANSFER PROTEIN; TRANSGENIC MICE; COMBINED HYPERLIPIDEMIA; PLASMA-LIPOPROTEINS; DIABETES-MELLITUS; ADIPOSE-TISSUE; MESSENGER-RNA; ATHEROSCLEROSIS; GENE;
Keywords:
oxidized LDL; acetylated LDL; cholesteryl ester transfer protein; HDL; reverse cholesterol transport;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Quintao, ECR Univ Sao Paulo, Sch Med, Lipid Lab LIM10, Sao Paulo, Brazil Univ Sao Paulo Sao Paulo Brazil b LIM10, Sao Paulo, Brazil
Citazione:
L.N. Castilho et al., "Oxidation of LDL enhances the cholesteryl ester transfer protein (CETP)-mediated cholesteryl ester transfer rate to HDL, bringing on a diminished nettransfer of cholesteryl ester from HDL to oxidized LDL", CLIN CHIM A, 304(1-2), 2001, pp. 99-106

Abstract

Cholesteryl ester transfer protein (CETP) plays a controversial role in atherogenesis by contributing to the net transfer of high density lipoprotein(HDL) cholesteryl ester (CE) to the liver via apolipoprotein-B-containing lipoproteins (apoB-LP). We evaluated in vitro the CETP-mediated bidirectional transfer of CE from HDL to the chemically modified pro-atherogenic low density lipoprotein (LDL) particles. Acetylated or oxidized (ox) LDL. eitherunlabeled or [H-3]-CE labeled. were incubated with [C-14]-CE-HDL in the presence of the lipoprotein-deficient plasma fraction (d>1.21 g/ml) as the source of CETP. The amount of radioactive CE transferred was determined afterdextran sulfate/MgCl2, precipitation of LDL. The results showed a 1.4-2.8-fold lower HDL-CE transfer to acetylated LDL while no effect was: observed on the CE transfer to oxidized LDL. However. the reverse transfer rate of [H-3]CE-LDL to HDL was 1.4-3.6 times greater when LDL was oxidized than whenit was intact. Overall, HDL, was better than HDL, as donor of CE to nativeLDL. probably reflecting the relatively greater CE content of HDL2. Oxidation of LDL enhanced the CETP-mediated cholesteryl ester transfer rate to HDL, bringing on a reduced net transfer rate of cholesteryl ester from HDL toox LDL. This may diminish the oxLDL particle's atherogenic effect. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 07/07/20 alle ore 19:04:55