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Titolo:
Various forms of plasma cysteine and its metabolites in patients undergoing hemodialysis
Autore:
Wlodek, PJ; Iciek, MB; Milkowski, A; Smolenski, OB;
Indirizzi:
Rydygier Hosp, Dept Nephrol, PL-31826 Krakow, Poland Rydygier Hosp Krakow Poland PL-31826 pt Nephrol, PL-31826 Krakow, Poland Jagiellonian Univ, Coll Med, Inst Med Biochem, PL-31034 Krakow, Poland Jagiellonian Univ Krakow Poland PL-31034 iochem, PL-31034 Krakow, Poland
Titolo Testata:
CLINICA CHIMICA ACTA
fascicolo: 1-2, volume: 304, anno: 2001,
pagine: 9 - 18
SICI:
0009-8981(200102)304:1-2<9:VFOPCA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONTAINING AMINO-ACIDS; MAINTENANCE HEMODIALYSIS; UREMIC PATIENTS; SULFANE SULFUR; GLUTATHIONE; HYPERHOMOCYSTEINEMIA; ACCUMULATION; DISEASE; MUSCLE; RATS;
Keywords:
end stage renal failure; hemodialysis; cysteine; cystine; sulfane sulfur; inorganic sulfate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Smolenski, OB Rydygier Hosp, Dept Nephrol, Os Zlotej Jesieni 1, PL-31826 Krakow, Poland Rydygier Hosp Os Zlotej Jesieni 1 Krakow Poland PL-31826 nd
Citazione:
P.J. Wlodek et al., "Various forms of plasma cysteine and its metabolites in patients undergoing hemodialysis", CLIN CHIM A, 304(1-2), 2001, pp. 9-18

Abstract

The thiol tripeptide glutathione (GSH) is particularly important as an antioxidative protector in the cells. GSH is also a form of storage and transport of cysteine. Under physiological conditions. the kidney plays an essential role in GSH biodegradation to free cysteine via gamma -glutamyl cycle and subsequently in further metabolism of this sulfur amino acid. Our aim was to assess to what degree renal insufficiency affects the level of variouscysteine farms and its metabolites (sulfates and sulfane sulfur compounds)in the plasma. and whole blood GSH levels. The concentrations of all the above mentioned sulfur compounds were measured in plasma of patients with end stage renal failure (ESRF) before and after dialysis and in a group of healthy controls. In plasma of patients with ESRF before dialysis tendency towards significant elevation of cystine, protein-bound cysteine and sulfateslevels was evident. Simultaneously, a decrease of plasma level of sulfane sulfur compounds, products of anaerobic sulfur metabolism, and whole blood GSH concentration was found. As a consequence, the ratio between the reduced cysteine and the total cysteine concentration was markedly decreased. Thedialysis session restore this ratio to the value observed in plasma of control individuals. These findings indicate disturbances in the thiol-disulfide equilibrium and show a higher oxidation status in plasma of patients with ESRF than in healthy controls. (C) 2001 Published by Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 15:54:31