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Titolo:
Experimental proof for the structure of a thrombin-inhibiting heparin molecule
Autore:
Petitou, M; Imberty, A; Duchaussoy, P; Driguez, PA; Ceccato, ML; Gourvenec, F; Sizun, P; Herault, JP; Perez, S; Herbert, JM;
Indirizzi:
Sanofi Synthelabo, Dept Cardiovasc Thrombose, F-31036 Toulouse, France Sanofi Synthelabo Toulouse France F-31036 bose, F-31036 Toulouse, France Univ Grenoble 1, CNRS, CERMAV, F-38041 Grenoble 9, France Univ Grenoble 1Grenoble France 9 RS, CERMAV, F-38041 Grenoble 9, France Sanofi Synthelabo, DARA, F-34184 Montpellier, France Sanofi Synthelabo Montpellier France F-34184 F-34184 Montpellier, France
Titolo Testata:
CHEMISTRY-A EUROPEAN JOURNAL
fascicolo: 4, volume: 7, anno: 2001,
pagine: 858 - 873
SICI:
0947-6539(20010216)7:4<858:EPFTSO>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLYCOSAMINO GLYCAN STRUCTURE; ANTITHROMBIN-III; OLIGOSACCHARIDE SYNTHESIS; BIOLOGICAL PROPERTIES; PROMOTED REACTIONS; VINYL GLYCOSIDES; HIGH-AFFINITY; PENTASACCHARIDE; FRAGMENTS; ACID;
Keywords:
antithrombin; glycosylations; heparin; oligosaccharides;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Petitou, M Sanofi Synthelabo, Dept Cardiovasc Thrombose, 195 Route Espagne, F-31036 Toulouse, France Sanofi Synthelabo 195 Route Espagne Toulouse France F-31036 ce
Citazione:
M. Petitou et al., "Experimental proof for the structure of a thrombin-inhibiting heparin molecule", CHEM-EUR J, 7(4), 2001, pp. 858-873

Abstract

Kinetic studies of thrombin inhibition by antithrombin in the presence of heparin have shown that thrombin binds to heparin in a preformed heparin - antithrombin complex. To study the relative position of the thrombin binding domain and the antithrombin binding domain on a heparin molecule we have designed and synthesized heparin mimetics which structurally are very similar to the genuine polysaccharide. Their inhibitory properties with respect to factor Xa and thrombin provide experimental evidence that in heparin thethrombin binding domain must be located at the nonreducing end of the antithrombin binding domain to observe thrombin inhibition. As expected, factorXa inhibition is not affected by elongation of the antithrombin binding pentasaccharide sequence, regardless of the position in which this elongationtakes place.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:42:59