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Titolo:
Paracrine regulation of apoptosis by steroid hormones in the male and female reproductive system
Autore:
Kurita, T; Wang, YZ; Donjacour, AA; Zhao, C; Lydon, JP; OMalley, BW; Isaacs, JT; Dahiya, R; Cunha, GR;
Indirizzi:
Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Dept Urol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Baylor Coll Med, Dept Mol & Cell Biol, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 l & Cell Biol, Houston, TX 77030 USA Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21231 USA Johns Hopkins Univ Baltimore MD USA 21231 Oncol, Baltimore, MD 21231 USA
Titolo Testata:
CELL DEATH AND DIFFERENTIATION
fascicolo: 2, volume: 8, anno: 2001,
pagine: 192 - 200
SICI:
1350-9047(200102)8:2<192:PROABS>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
UTERINE EPITHELIAL-CELLS; EPIDERMAL GROWTH-FACTOR; RAT VENTRAL PROSTATE; FEMINIZED TFM/Y MICE; PROGESTERONE-RECEPTOR; ESTROGEN-RECEPTOR; MOUSE UTERUS; FACTOR-BETA; FACTOR-I; LUMINAL EPITHELIUM;
Keywords:
mouse; epithelial-stromal tissue interaction; androgen; testosterone; dihydrotestosterone (DHT); androgen receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Cunha, GR Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USAUniv Calif San Francisco San Francisco CA USA 94143 A 94143 USA
Citazione:
T. Kurita et al., "Paracrine regulation of apoptosis by steroid hormones in the male and female reproductive system", CELL DEAT D, 8(2), 2001, pp. 192-200

Abstract

In males, androgens are essential in maintaining the integrity of the prostate. Androgen-ablation induces apoptosis of the prostatic epithelium. In females, ovariectomy induces apoptosis in uterine epithelium while progesterone inhibits this process, The objective of this study was to determine whether androgen and progesterone inhibit apoptosis, respectively, in mouse prostatic and uterine epithelia via steroid receptors in the epithelium or inthe stroma, To address this question, prostatic tissue recombinants were prepared with rat urogenital sinus mesenchyme plus bladder epithelium from wild-type or testicular feminization mutant (Tfm) mice, Thus, prostatic tissue was generated having androgen receptor (AR) in both epithelium and stroma or in the stroma only. Castration of hosts induced apoptosis in the AR-negative Tfm prostatic epithelium with an epithelial apoptotic index virtually identical to prostatic tissue recombinants containing wild-type epithelium, Moreover, this castration-induced prostatic epithelial apoptosis was blocked by testosterone and dihydrotestosterone in both wild-type and Tfm prostatic tissue recombinants, Likewise, uterine tissue recombinants were prepared in which epithelium and/or stroma was devoid of progesterone receptor (PR) by using uterine epithelium and stroma of wild-type and PR knockout mice. Progesterone inhibited uterine epithelial apoptosis only in tissue recombinants prepared with PR-positive stroma, The PR status of the epithelium did not affect epithelial apoptotic index. Therefore, the apoptosis in prostatic and uterine epithelia is regulated by androgen and progesterone via stromal AR and PR, respectively. In both cases, epithelial AR or PR is not required for hormonal regulation of epithelial apoptosis in prostatic and uterine epithelium.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 10:11:32