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Titolo:
Early stages of p53-induced apoptosis are reversible
Autore:
Geske, FJ; Lieberman, R; Strange, R; Gerschenson, LE;
Indirizzi:
Univ Colorado, Hlth Sci Ctr, Dept Pathol, Denver, CO 80262 USA Univ Colorado Denver CO USA 80262 Ctr, Dept Pathol, Denver, CO 80262 USA AMC Canc Res Ctr, Lakewood, CO USA AMC Canc Res Ctr Lakewood CO USAAMC Canc Res Ctr, Lakewood, CO USA
Titolo Testata:
CELL DEATH AND DIFFERENTIATION
fascicolo: 2, volume: 8, anno: 2001,
pagine: 182 - 191
SICI:
1350-9047(200102)8:2<182:ESOPAA>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
LI-FRAUMENI SYNDROME; DNA-DAMAGE; EXCISION-REPAIR; HUMAN-CELLS; P53; DEATH; PHOSPHATIDYLSERINE; FRAGMENTS; INDUCTION; CLEAVAGE;
Keywords:
p53; apoptosis; phosphatidylserine; DNA repair; aphidicolin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Gerschenson, LE Univ Colorado, Hlth Sci Ctr, Dept Pathol, Box B216,4200 E 9th Ave, Denver,CO 80262 USA Univ Colorado Box B216,4200 E 9th Ave Denver CO USA 80262
Citazione:
F.J. Geske et al., "Early stages of p53-induced apoptosis are reversible", CELL DEAT D, 8(2), 2001, pp. 182-191

Abstract

Apoptosis is a type of physiological cell death that occurs during development, normal tissue homeostasis, or as a result of different cellular insults. The phenotype of an apoptotic cell is relatively consistent in most cases of apoptosis and involves at least changes in the cell membrane, proteolysis of cytoplasmic and nuclear proteins, and eventual destruction of nuclear DNA, Our laboratory is interested in the reversibility of apoptosis. We have initial evidence that DNA repair is activated early in p53-induced apoptosis and may be involved in its reversibility. The present work further strengthens our proposition that p53-induced apoptosis is reversible. Weshowthat p53 activation induces phosphatidylserine (PS) externalization early in apoptosis, and that these early apoptotic cells with externalized PS canbe rescued and proliferate if the apoptotic stimulus is removed. In addition, we show that unscheduled DNA synthesis occurs in early apoptotic cells,and that if DNA repair is inhibited by aphidicolin, apoptosis is accelerated. These results confirm that early p53-induced apoptotic cells can be rescued from the apoptotic program, and that DNA repair can modulate that celldeath process.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 13:29:18