Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Resistance to melanoma metastases in mice selected for high acute inflammatory response
Autore:
Maria, DA; Ribeiro, OG; Pizzocaro, KF; De Franco, M; Cabrera, WK; Starobinas, N; Gallois, V; Siqueira, M; Seman, M; Ibanez, OM;
Indirizzi:
Inst Butantan, Lab Imunogenet, BR-05503900 Sao Paulo, Brazil Inst Butantan Sao Paulo Brazil BR-05503900 BC-05503900 Sao Paulo, Brazil Univ Paris 07, Lab Immunodifferenciat, Paris, France Univ Paris 07 ParisFrance is 07, Lab Immunodifferenciat, Paris, France
Titolo Testata:
CARCINOGENESIS
fascicolo: 2, volume: 22, anno: 2001,
pagine: 337 - 342
SICI:
0143-3334(200102)22:2<337:RTMMIM>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VITRO; TUMOR; CANCER; CELLS; LINES; NEUTROPHILS; GENETICS; CARCINOGENESIS; RESPONSIVENESS; TUMORIGENESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Ibanez, OM Inst Butantan, Lab Imunogenet, Avenida Vital Brazil 1500, BR-05503900 Sao Paulo, Brazil Inst Butantan Avenida Vital Brazil 1500 Sao PauloBrazil BR-05503900 BC
Citazione:
D.A. Maria et al., "Resistance to melanoma metastases in mice selected for high acute inflammatory response", CARCINOGENE, 22(2), 2001, pp. 337-342

Abstract

The role of innate immunity in natural resistance to tumor progression wasinvestigated in two mouse lines, AIRmax and AIRmin, selected by bi-directional selective breeding on the basis of high or low acute inflammatory response. Compared with AIRmin, AIRmax mice were shown to be resistant to 7,12-dimethylbenz[a]anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate-induced skin cancers and here we demonstrate that AIRmax are also able to restrain the development of metastases upon transfer of MHC compatible, incompatible or xenogeneic melanomas, An acute inflammatory response to melanoma cells was observed in AIRmax mice only, although both lines were found to mount similar specific immune responses to melanoma antigens, The genetically selected lines therefore represent a model system to analyze the positive correlation between multiple resistance to tumorigenesis and host inflammatory responsiveness.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 05:13:33