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Titolo:
Does CDP-choline modulate phospholipase activities after transient forebrain ischemia?
Autore:
Rao, AM; Hatcher, JF; Dempsey, RJ;
Indirizzi:
Univ Wisconsin, Dept Neurol Surg, Ctr Clin Sci, Madison, WI 53792 USA UnivWisconsin Madison WI USA 53792 , Ctr Clin Sci, Madison, WI 53792 USA Univ Wisconsin, Cardiovasc Res Ctr, Madison, WI 53792 USA Univ Wisconsin Madison WI USA 53792 iovasc Res Ctr, Madison, WI 53792 USA Vet Adm Hosp, Madison, WI USA Vet Adm Hosp Madison WI USAVet Adm Hosp, Madison, WI USA
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 893, anno: 2001,
pagine: 268 - 272
SICI:
0006-8993(20010302)893:1-2<268:DCMPAA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT-BRAIN; POSTISCHEMIC REPERFUSION; CEREBRAL-ISCHEMIA; ARACHIDONIC-ACID; OXIDATIVE STRESS; GERBIL BRAIN; CITICOLINE; APOPTOSIS; NEUROPROTECTION; MECHANISMS;
Keywords:
arachidonic acid; apoptosis, cardiolipin; citicoline; lysophospholipids, mitochondria; neuronal death; phosphatidylcholine; phosphatidylinositol; phospholipase A(2);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Rao, AM Univ Wisconsin, Dept Neurol Surg, Ctr Clin Sci, 600 Highland Ave,H4-330, Madison, WI 53792 USA Univ Wisconsin 600 Highland Ave,H4-330 MadisonWI USA 53792 92 USA
Citazione:
A.M. Rao et al., "Does CDP-choline modulate phospholipase activities after transient forebrain ischemia?", BRAIN RES, 893(1-2), 2001, pp. 268-272

Abstract

Ten min forebrain ischemia/1-day reperfusion resulted in significant decreases in total phosphatidylcholine (PtdCho), phosphatidylinositol (PtdIns), and cardiolipin in gerbil hippocampus. CDP-choline restored cardiolipin levels, arachidonic acid content of PtdCho, partially but significantly restored total PtdCho, and had no effect on PtdIns. These data suggest that CDP-choline prevented the activation of phospholipase A(2) (rather than inhibiting phospholipase A(2) activity) but did not affect activities: of PtdCho-phospholipases C and/or D, or phosphoinositide-phospholipase C. CDP-choline also provided significant protection for hippocampal CA(1) neurons. (C) 2001Elsevier Science B.V. All rights reserved.

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Documento generato il 14/07/20 alle ore 19:26:23