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Titolo:
The estrous cycle affects pseudorabies virus (PRV) infection of the CNS
Autore:
Weiss, ML; Dobbs, ME; MohanKumar, PS; Chowdhury, SI; Sawrey, K; Guevara-Guzman, R; Huang, J;
Indirizzi:
Kansas State Univ, Coll Vet Med, Dept Anat & Physiol, Manhattan, KS 66506 USA Kansas State Univ Manhattan KS USA 66506 Physiol, Manhattan, KS 66506 USA Michigan State Univ, Coll Vet Med, Dept Vet Pathol, E Lansing, MI 48824 USA Michigan State Univ E Lansing MI USA 48824 athol, E Lansing, MI 48824 USA Kansas State Univ, Dept Diagnost Med Pathobiol, Manhattan, KS 66506 USA Kansas State Univ Manhattan KS USA 66506 thobiol, Manhattan, KS 66506 USA UNAM, Fac Med, Dept Fisiol, Mexico City, DF, Mexico UNAM Mexico City DF Mexico Fac Med, Dept Fisiol, Mexico City, DF, Mexico
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 893, anno: 2001,
pagine: 215 - 226
SICI:
0006-8993(20010302)893:1-2<215:TECAPV>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
PITUITARY-ADRENAL AXIS; COLLAGEN-INDUCED ARTHRITIS; FEMALE REPRODUCTIVE-TRACT; CENTRAL-NERVOUS-SYSTEM; SEX STEROID REGULATION; AFFERENT-FIBERS; PELVIC NERVE; PREGANGLIONIC NEURONS; HYPOGASTRIC NERVE; MUCOSAL IMMUNITY;
Keywords:
cervix; alpha-herpesvirus; kidney; reproductive system; viral tract tracing; estrogen; trans-synaptic transport;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
73
Recensione:
Indirizzi per estratti:
Indirizzo: Weiss, ML Kansas State Univ, Coll Vet Med, Dept Anat & Physiol, 1600 Denison Ave,Coles Hall 105, Manhattan, KS 66506 USA Kansas State Univ 1600 Denison Ave,Coles Hall 105 Manhattan KS USA 66506
Citazione:
M.L. Weiss et al., "The estrous cycle affects pseudorabies virus (PRV) infection of the CNS", BRAIN RES, 893(1-2), 2001, pp. 215-226

Abstract

Previous work had suggested that mucosal immunity may be affected by the stage of the estrous cycle. Here, susceptibility to a neurotropic virus infection at different stages of the estrous cycle was assessed in a rodent model after direct injection of the virus into visceral organs. in the first two experiments, female Sprague-Dawley rats were infected with pseudorabies virus (PRV, Bartha's K-strain) by injection into either the cervix or the kidney after monitoring their estrous cycle. After either 4- or 5-day survival period post-infection, the rats were euthanized by transcardially perfusion and peripheral and central nervous system tissues were removed for immunocytochemical staining. The number of infected neurons was counted in various regions. Statistical analysis revealed that: (1) the number of infectedcells in the sympathetic or parasympathetic ganglion, or the dorsal root ganglia was not affected regardless of the stage of the estrous cycle after cervix injection with PRV; (2) in contrast, the number of infected neurons in the spinal cord was affected significantly by the stage of the estrous cycle during viral infection of the cervix; (3) after kidney infection, the number of infected neurons found within the spinal cord or dorsal root ganglia varied significantly across the estrous cycle. In both cases, animals infected in proestrus or estrus had fewer infected neurons than animals: infected in diestrus I or diestrus II (proestrous and estrous animals had lessthan 20% of infected cells found in diestrus I or diestrus II rats). In the third experiment, older, persistent estrous or persistent diestrous rats were infected by kidney injection and given a 4-day survival period, prior to virus isolation from lower thoracic spinal cord. Animals in persistent estrous had significantly less virus per gram of tissue than the persistent diestrous rats. These data suggest that the CNS of animals in proestrus or estrus is less susceptible to PRV infection compared to animals in either diestrus I or diestrus II. Because estrogen replacement therapy is known to restore some immune functions during reproductive ageing, it is speculated that plasma estrogen levels modulate the central nervous system's susceptibility to viral infections. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 09:19:35