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Titolo:
Central corticotropin releasing factor (CRF) and adrenergic receptors mediate hemodynamic responses to cocaine
Autore:
Dong, HW; Gan, Q; Knuepfer, MM;
Indirizzi:
St Louis Univ, Sch Med, Dept Pharmacol & Physiol Sci, St Louis, MO 63104 USA St Louis Univ St Louis MO USA 63104 & Physiol Sci, St Louis, MO 63104 USA
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 893, anno: 2001,
pagine: 1 - 10
SICI:
0006-8993(20010302)893:1-2<1:CCRF(A>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; DIFFERENTIAL CARDIOVASCULAR SENSITIVITY; SPONTANEOUSLY HYPERTENSIVE RATS; CONSCIOUS RATS; HEART-RATE; PLASMA-CORTICOSTERONE; INDUCED ELEVATION; MECHANISMS; STRESS; ANTAGONISTS;
Keywords:
cocaine; alpha-helical CRF9-41; astressin; propranolol; yohimbine; hemodynamic response; cardiac output; intracerebroventricular administration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Knuepfer, MM St Louis Univ, Sch Med, Dept Pharmacol & Physiol Sci, 1402 S Grand Blvd, St Louis, MO 63104 USA St Louis Univ 1402 S Grand Blvd St LouisMO USA 63104 104 USA
Citazione:
H.W. Dong et al., "Central corticotropin releasing factor (CRF) and adrenergic receptors mediate hemodynamic responses to cocaine", BRAIN RES, 893(1-2), 2001, pp. 1-10

Abstract

Cocaine administration evokes cardiovascular responses that are variable in rats such that the presser response is attributable to either a large increase in systemic vascular resistance and a decrease in cardiac output (vascular responders) or a smaller increase in systemic vascular resistance andno change or an increase in cardiac output (mixed responders). This study was designed to determine the role of central corticotropin releasing factor (CRF) and adrenergic receptors in mediating specific hemodynamic responsepatterns. Rats were instrumented for ascending aortic blood flow determination (cardiac output) using a pulsed Doppler system, arterial pressure measurement and for intravenous and intracerebroventricular (icv) administration of drugs. After characterizing the hemodynamic response pattern in individual rats to cocaine (5 mg/kg, i.v., 4-6 trials), selective receptor antagonists were administered icy 10 min before cocaine (5 mg/kg, i.v.). Pretreatment with the CRF antagonist alpha -helical CRF9-41 (10 mug/5 mul, icv) prevented the decrease in cardiac output in vascular responders without altering hemodynamic responses to cocaine in mixed responders. Astressin (5 mug/5mul, icv) exerted a similar effect in vascular responders. The alpha (2) receptor antagonist, yohimbine (3 mug/mul, icv) also prevented the decrease in cardiac output in vascular responders. Lower doses of alpha -helical CRF9-41 (1 and 3 mug) were ineffective whereas higher doses of either CRF antagonist were lethal within 24 h. In contrast, propranolol (3 or 30 mug. icv)pretreatment enhanced the cocaine-induced decrease in cardiac output and increase in systemic vascular resistance noted in vascular responders and resulted in a decrease in cardiac output in mixed responders. We conclude that CRF and adrenoceptors in the CNS play an important role in determining the hemodynamic response pattern to cocaine. Furthermore, central beta -adrenoceptors may be responsible for the reported effects of intravenous propranolol on cocaine-induced responses. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 07:35:17