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Titolo:
The interphase microtubule damage checkpoint defines an S-phase commitmentpoint and does not require p21(waf-1)
Autore:
Mantel, CR; Braun, SE; Lee, Y; Kim, YJ; Broxmeyer, HE;
Indirizzi:
Indiana Univ, Sch Med, Walther Oncol Ctr, Dept Microbiol Immunol, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 mmunol, Indianapolis, IN 46202 USA Walther Canc Inst, Indianapolis, IN USA Walther Canc Inst Indianapolis INUSA er Canc Inst, Indianapolis, IN USA
Titolo Testata:
BLOOD
fascicolo: 5, volume: 97, anno: 2001,
pagine: 1505 - 1507
SICI:
0006-4971(20010301)97:5<1505:TIMDCD>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
MICE LACKING; CELLS; INHIBITORS; MECHANISMS; APOPTOSIS; MITOSIS; ARREST; G(2); P53; P21;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Mantel, CR Indiana Univ, Sch Med, Walther Oncol Ctr, Dept Microbiol Immunol, 1044 W Walnut St, Indianapolis, IN 46202 USA Indiana Univ 1044 W Walnut St Indianapolis IN USA 46202 202 USA
Citazione:
C.R. Mantel et al., "The interphase microtubule damage checkpoint defines an S-phase commitmentpoint and does not require p21(waf-1)", BLOOD, 97(5), 2001, pp. 1505-1507

Abstract

Cell cycle checkpoints ensure orderly progression of events during cell division. A microtubule damage (MTD)-induced checkpoint has been described inG(1) phase of the cell cycle (G(1)MTC) for which little is known. The present study shows that the G(1)MTC is intact in activated T lymphocytes from mice with the p21(waf-1) gene deleted. However, p21(waf-1) gene deletion does affect the ratio of cells that arrest at the G(1)MTC and the spindle checkpoint after MTD. The G(1)MTC arrests T lymphocytes in G(1) prior to cdc2 up-regulation and prior to G(1) arrest by p21(waf-1). Once cells have progressed past the G(1)MTC, they are committed to chromosome replication and metaphase progression, even with extreme MTD. The G(1)MTC is also present in a human myeloid cell line deficient in p21(waf-1) gene expression. The p21-independent G(1)MTC may be important in cellular responses to MTD such as those induced by drugs used to treat cancer. (Blood, 2001;97:1505-1507) (C) 2001 by The American Society of Hematology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:34:21