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Titolo:
Factors affecting thymic function after allogeneic hematopoietic stem celltransplantation
Autore:
Weinberg, K; Blazar, BR; Wagner, JE; Agura, E; Hill, BJ; Smogorzewska, M; Koup, RA; Betts, MR; Collins, RH; Douek, DC;
Indirizzi:
Childrens Hosp Los Angeles, Div Res Immunol Bone Marrow Transplantat, Los Angeles, CA 90027 USA Childrens Hosp Los Angeles Los Angeles CA USA 90027 Angeles, CA 90027 USA Univ Minnesota, Ctr Canc, Dept Pediat, Div Bone Marrow Transplantat, Minneapolis, MN USA Univ Minnesota Minneapolis MN USA rrow Transplantat, Minneapolis, MN USA Univ Texas, SW Med Ctr, Dept Internal Med, Dallas, TX USA Univ Texas Dallas TX USA , SW Med Ctr, Dept Internal Med, Dallas, TX USA Baylor Univ, Med Ctr, Sammons Canc Ctr, Dallas, TX USA Baylor Univ DallasTX USA niv, Med Ctr, Sammons Canc Ctr, Dallas, TX USA
Titolo Testata:
BLOOD
fascicolo: 5, volume: 97, anno: 2001,
pagine: 1458 - 1466
SICI:
0006-4971(20010301)97:5<1458:FATFAA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW TRANSPLANTATION; VERSUS-HOST-DISEASE; TOTAL-BODY IRRADIATION; UMBILICAL-CORD-BLOOD; HIGH-DOSE ETOPOSIDE; CD4(+) T-CELLS; CYCLOSPORINE-A; TREATED RATS; GRAFT; LYMPHOCYTES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Weinberg, K Childrens Hosp Los Angeles, Div Res Immunol Bone Marrow Transplantat, Mailstop 62,4650 Sunset Blvd, Los Angeles, CA 90027 USA Childrens Hosp Los Angeles Mailstop 62,4650 Sunset Blvd Los Angeles CA USA 90027
Citazione:
K. Weinberg et al., "Factors affecting thymic function after allogeneic hematopoietic stem celltransplantation", BLOOD, 97(5), 2001, pp. 1458-1466

Abstract

Hematopoietic stem cell transplantation (HSCT) is followed by profound immunodeficiency. Thymic function is necessary for de novo generation of T cells after HSCT. Circulating CD45RA(+) naive T-cell levels are predictive of antigen-specific T-cell responses in the absence of graft-versus-host disease (GVHD). These T cells may not represent recent thymic emigrants, since naive T cells may maintain this phenotype if not antigen-activated. To accurately measure thymic output after HSCT and determine the factors that influence thymic function, T-cell receptor excision circles (TRECs) were examined in CD4(+) and CD8(+) cells from a cross-section of patients following HSCT. TREC levels rose weeks after HSCT and could be detected in patients 6 years after HSCT. TREC levels correlated with the frequency of phenotypicallynaive T cells, indicating that such cells were not expanded progeny of naive T cells present in the donor graft. Chronic GVHD was the most important factor that predicted low TREC levels even years after HSCT. Patients with a history of resolved GVHD had decreased numbers of TREC, compared with those with no GVHD. Because few adults had no history of GVHD, it was not possible to determine whether age alone inversely correlated with TREC levels. Recipients of cord blood grafts had no evidence of decreased TREC induced by immunosuppressive prophylaxis drugs. Compared with unrelated donor grafts, recipients of matched sibling grafts had higher TREC levels. Collectively, these data suggest that thymopoiesis is inhibited by GVHD. Larger studieswill be needed to determine the independent contributions of age and preparative regimen to posttransplant thymopoietic capacity. (Blood. 2001;91:1458-1466) (C) 2001 by The American Society of Hematology.

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Documento generato il 23/09/20 alle ore 12:06:54