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Titolo:
Expression of Fas/Fas ligand by decidual leukocytes in hydatidiform mole
Autore:
Wongweragiat, S; Searle, RF; Bulmer, JN;
Indirizzi:
Royal Victoria Infirm, Dept Pathol, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England Royal Victoria Infirm Newcastle Upon Tyne Tyne & Wear England NE1 4LP and Royal Victoria Infirm, Dept Microbiol & Immunol, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England Royal Victoria Infirm Newcastle Upon Tyne Tyne & Wear England NE1 4LP and Royal Victoria Infirm, Dept Obstet & Gynaecol, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England Royal Victoria Infirm Newcastle Upon Tyne Tyne & Wear England NE1 4LP and
Titolo Testata:
BIOLOGY OF REPRODUCTION
fascicolo: 3, volume: 64, anno: 2001,
pagine: 784 - 789
SICI:
0006-3363(200103)64:3<784:EOFLBD>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN CHORIONIC VILLI; HUMAN T-LYMPHOCYTES; FIRST-TRIMESTER; FAS LIGAND; HUMAN PLACENTA; INHIBITORY RECEPTORS; ANTIGEN EXPRESSION; BCL-2 EXPRESSION; APOPTOSIS; CELLS;
Keywords:
apoptosis; pregnancy; reproductive immunology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Bulmer, JN Royal Victoria Infirm, Dept Pathol, Victoria Rd, Newcastle UponTyne NE1 4LP, Tyne & Wear, England Royal Victoria Infirm Victoria Rd Newcastle Upon Tyne Tyne & Wear England NE1 4LP
Citazione:
S. Wongweragiat et al., "Expression of Fas/Fas ligand by decidual leukocytes in hydatidiform mole", BIOL REPROD, 64(3), 2001, pp. 784-789

Abstract

Complete hydatidiform moles are entirely paternally derived and, therefore, represent a complete intrauterine allograft that might be expected to provoke an altered maternal immune response compared with that of normal pregnancy. Uterine decidua contains a large leukocyte population, of which 10%-20% are T lymphocytes. Fas ligand (FasL) expression by placental trophoblastmay induce apoptosis of Fas+ lymphocytes, thereby facilitating immune tolerance and survival of the molar trophoblast. Our previous studies have shown an increase in activated CD4+ decidual T cells in molar pregnancy compared with normal pregnancy. This study was designed to characterize and quantitate Fas/FasL expression by decidual leukocytes in complete and partial hydatidiform mole compared with that in normal early pregnancy using single and double immunohistochemical labeling (i.e., avidin-biotin-peroxidase and avidin biotin-alkaline phosphatase). A significant increase was found in Fasand FasL expression by decidual CD4+ T cells in complete (Fas+, P = 0.0106; FasL+, P = 0.0081) and partial (Fas+, P = 0.0131; FasL+, P = 0.0051),hydatidiform moles, as was a significant decrease in Fas expression by decidualCD8+ T cells in complete (P = 0.0137) and partial (P = 0.0202) hydatidiform mole compared with normal early pregnancy. The implications of altered Fas/FasL status of decidual T-cell subsets in hydatidiform mole are also discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:46:00