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Titolo:
Negative feedback regulation of the secretion and actions of gonadotropin-releasing hormone in males
Autore:
Tilbrook, AJ; Clarke, IJ;
Indirizzi:
Monash Univ, Dept Physiol, Clayton, Vic 3800, Australia Monash Univ Clayton Vic Australia 3800 siol, Clayton, Vic 3800, Australia Prince Henrys Inst Med Res, Clayton, Vic 3168, Australia Prince Henrys Inst Med Res Clayton Vic Australia 3168 Vic 3168, Australia
Titolo Testata:
BIOLOGY OF REPRODUCTION
fascicolo: 3, volume: 64, anno: 2001,
pagine: 735 - 742
SICI:
0006-3363(200103)64:3<735:NFROTS>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOLLICLE-STIMULATING-HORMONE; MONKEY MACACA-MULATTA; MALE RHESUS-MONKEY; RECOMBINANT INHIBIN-A; PROOPIOMELANOCORTIN MESSENGER-RNA; RECEPTOR-IMMUNOREACTIVE CELLS; ARCUATE-VENTROMEDIAL REGION; PULSATILE LH-SECRETION; CASTRATED MALE SHEEP; LUTEINIZING-HORMONE;
Keywords:
follicle-stimulating hormone; gonadotropin-releasing hormone; inhibin; luteinizing hormone; neuroendocrinology; testosterone;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
97
Recensione:
Indirizzi per estratti:
Indirizzo: Tilbrook, AJ Monash Univ, Dept Physiol, POB 13F, Clayton, Vic 3800, Australia Monash Univ POB 13F Clayton Vic Australia 3800 800, Australia
Citazione:
A.J. Tilbrook e I.J. Clarke, "Negative feedback regulation of the secretion and actions of gonadotropin-releasing hormone in males", BIOL REPROD, 64(3), 2001, pp. 735-742

Abstract

This minireview considers the state of knowledge regarding the interactions of testicular hormones to regulate the secretion and actions of GnRH in males, with special focus on research conducted in rams and male rhesus monkeys. In these two species, LH secretion is under the negative feedback regulation of testicular steroids that act predominantly within the central nervous system to suppress GnRH secretion. The extent to which these actions of testicular steroids result from the direct actions of testosterone or itsprimary metabolites, estradiol or dihydrotestosterone, is unclear. BecauseGnRH neurons do not contain steroid receptors, the testicular steroids must influence GnRH neurons via afferent neurons, which are largely undefined. The feedback regulation of FSH is controlled by inhibin acting directly atthe pituitary gland. In male rhesus monkeys, the feed-back regulation of FSH secretion is accounted for totally by the physiologically relevant form of inhibin, which appears to be inhibin B. In rams, the feedback regulationof FSH secretion involves the actions of inhibin and testosterone and interactions between these hormones, but the physiologically relevant form of inhibin has not been determined. The mechanisms of action for inhibin are not known.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 08:10:58