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Titolo:
Elevated motor threshold in drug-free, cocaine-dependent patients assessedwith transcranial magnetic stimulation
Autore:
Boutros, NN; Lisanby, SH; Tokuno, H; Torello, MW; Campbell, D; Berman, R; Malison, R; Krystal, JH; Kosten, T;
Indirizzi:
Yale Univ, Sch Med, VA Connecticut Hlth Syst, W Haven, CT 06516 USA Yale Univ W Haven CT USA 06516 nnecticut Hlth Syst, W Haven, CT 06516 USA Capital Univ, Columbus, OH USA Capital Univ Columbus OH USACapital Univ, Columbus, OH USA Connecticut Mental Hlth Ctr, New Haven, CT USA Connecticut Mental Hlth Ctr New Haven CT USA Hlth Ctr, New Haven, CT USA Columbia Univ, New York, NY USA Columbia Univ New York NY USAColumbia Univ, New York, NY USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 4, volume: 49, anno: 2001,
pagine: 369 - 373
SICI:
0006-3223(20010215)49:4<369:EMTIDC>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-AMINOBUTYRIC-ACID; EVOKED-POTENTIALS; CORTICAL EXCITABILITY; PARKINSONS-DISEASE; NUCLEUS-ACCUMBENS; SILENT PERIOD; INHIBITION; CORTEX; BRAIN; SENSITIZATION;
Keywords:
TMS; cocaine; motor threshold; cortical excitability; inhibition; motor cortex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Boutros, NN Yale Univ, Sch Med, VA Connecticut Hlth Syst, 950 Campbell Ave, W Haven, CT 06516 USA Yale Univ 950 Campbell Ave W Haven CT USA 06516 , CT 06516 USA
Citazione:
N.N. Boutros et al., "Elevated motor threshold in drug-free, cocaine-dependent patients assessedwith transcranial magnetic stimulation", BIOL PSYCHI, 49(4), 2001, pp. 369-373

Abstract

Background: Transcranial magnetic stimulation (TMS) provides a noninvasivemethod of examining cortical inhibitory and excitatory processes and cortical excitability in awake subjects. There is evidence from clinical and electroencephalographic (EEG) data that cortical excitability may be abnormal in some psychiatric populations. Chronic cocaine abuse influences a number of neurotransmitters that are involved in the excitatory/inhibitory balanceof the cerebral cortex. This pilot study was conducted to ascertain the possible utility of TMS in examining cortical excitability in a population ofchronic cocaine abusers. Methods: The right and left motor thresholds of ten cocaine-dependent subjects, according to DSM-IV, and ten normal control subjects were examined using single pulse TMS. Results: The resting motor thresholds resulting from stimulation of the right or the left motor cortical regions were significantly elevated in cocaine-dependent subjects compared with matched control subjects. Conclusions: These pilot data suggest that chronic cocaine use significantly alters cortical excitability in the direction of increased inhibition ordecreased excitability, We hypothesize that this observation reflects adaptation to those effects of cocaine intoxication that promote cortical excitability and seizures., (C) 2001 Society of Biological Psychiatry.

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Documento generato il 03/04/20 alle ore 05:47:43