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Titolo:
[I-123] beta-CIT and single photon emission computed tomography reveal reduced brain serotonin transporter availability in bulimia nervosa
Autore:
Tauscher, J; Pirker, W; Willeit, M; de Zwaan, M; Bailer, U; Neumeister, A; Asenbaum, S; Lennkh, C; Praschak-Rieder, N; Brucke, T; Kasper, S;
Indirizzi:
Univ Vienna, Dept Gen Psychiat, A-1010 Vienna, Austria Univ Vienna Vienna Austria A-1010 t Gen Psychiat, A-1010 Vienna, Austria Univ Vienna, Dept Clin Neurol, A-1010 Vienna, Austria Univ Vienna ViennaAustria A-1010 pt Clin Neurol, A-1010 Vienna, Austria Univ Vienna, Dept Nucl Med, A-1010 Vienna, Austria Univ Vienna Vienna Austria A-1010 Dept Nucl Med, A-1010 Vienna, Austria Wilhelminenspital Stadt Wien, Vienna, Austria Wilhelminenspital Stadt Wien Vienna Austria Stadt Wien, Vienna, Austria
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 4, volume: 49, anno: 2001,
pagine: 326 - 332
SICI:
0006-3223(20010215)49:4<326:[BASPE>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
NOREPINEPHRINE UPTAKE SITES; IN-VIVO; DOPAMINE TRANSPORTERS; BINDING-KINETICS; SPECT; 2-BETA-CARBOMETHOXY-3-BETA-(4-IODOPHENYL)TROPANE; AUTORADIOGRAPHY; VISUALIZATION; EXPERIENCE; DEPRESSION;
Keywords:
bulimia nervosa; SPECT; [I-123] beta-CIT; serotonin transporter; eating disorders;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Tauscher, J Ctr Addict & Mental Hlth, PET Ctr, 250 Coll St, Toronto, ON M5T 1R8, Canada Ctr Addict & Mental Hlth 250 Coll St Toronto ON Canada M5T 1R8
Citazione:
J. Tauscher et al., "[I-123] beta-CIT and single photon emission computed tomography reveal reduced brain serotonin transporter availability in bulimia nervosa", BIOL PSYCHI, 49(4), 2001, pp. 326-332

Abstract

Background: Impaired serotonin transmission has been implicated in the pathophysiology of eating disorders. We investigated the in vivo availability of brain serotonin transporters and dopamine transporters in bulimia nervosa patients. Methods: Approximately 24 hours after injection of [I-123]-2 beta -carbomethoxy-3 beta-(4-iodophenyl)tropane([I-123] beta -CIT), single photon emission computed tomography scans were performed in 10 medication-free, female bulimic patients and 10 age-matched healthy females. For quantification of brain serotonin transporter and dopamine transporter availability, a ratio of specific to non-specific [I-123] beta -CIT brain binding was used (V-3" =target region - cerebellum/cerebellum). Results: Drug-free bulimia nervosa patients showed a 17% reduced brain serotonin transporter availability in the hypothalamus and thalamus, as compared with healthy control subjects (2.4 +/- 0.4 vs. 2.9 +/- 0.4, p = .026), and a similar reduction in striatal dopamine transporter availability. Therewas a negative correlation of illness duration and serotonin transporter availability (r = -.65; p = .042) and a strong positive correlation between hypothalmic/thalamic and striatal V-3" (r = .80, p < .001). Conclusions: This first report of reduced [I-123] <beta>-CIT binding in a relatively small group of patients with bulimia nervosa suggests a reduced hypothalamic and thalamic serotonin transporter availability in bulimia, which is more pronounced with longer duration of illness. (C) 2001 Society ofBiological Psychiatry.

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Documento generato il 17/09/19 alle ore 23:00:00