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Titolo:
Noradrenergic dysfunction in the prefrontal cortex in depression: An [O-15] H2OPET study of the neuromodulatory effects of clonidine
Autore:
Fu, CHY; Reed, LJ; Meyer, JH; Kennedy, S; Houle, S; Eisfeld, BS; Brown, GM;
Indirizzi:
Inst Psychiat, Div Psychol Med, London SE5 8AF, England Inst Psychiat London England SE5 8AF sychol Med, London SE5 8AF, England Univ Toronto, Ctr Addict & Mental Hlth, Toronto, ON, Canada Univ Toronto Toronto ON Canada Addict & Mental Hlth, Toronto, ON, Canada
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 4, volume: 49, anno: 2001,
pagine: 317 - 325
SICI:
0006-3223(20010215)49:4<317:NDITPC>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; GROWTH-HORMONE RESPONSE; IDAZOXAN BINDING-SITES; GH-RELEASING HORMONE; CEREBRAL BLOOD-FLOW; OLD-WORLD MONKEY; HUMAN BRAIN; MAJOR DEPRESSION; SUSTAINED ATTENTION; COGNITIVE FUNCTION;
Keywords:
clonidine; depression; imidazoline; alpha(2)-adrenergic; PET; prefrontal cortex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Fu, CHY Inst Psychiat, Div Psychol Med, De Crespigny Pk, London SE5 8AF, England Inst Psychiat De Crespigny Pk London England SE5 8AF 8AF, England
Citazione:
C.H.Y. Fu et al., "Noradrenergic dysfunction in the prefrontal cortex in depression: An [O-15] H2OPET study of the neuromodulatory effects of clonidine", BIOL PSYCHI, 49(4), 2001, pp. 317-325

Abstract

Background: Noradrenergic dysfunction has been consistently implicated in depression. Much of the evidence, though, has been indirect, such as an attenuated growth hormone response to the alpha (2)-adrenoceptor agonist clonidine. To more directly examine central functioning of the noradrenergic system in depression, we have used [O-15] H2O positron emission tomography (PET) to measure cerebral blood flow (rCBF) in combination with clonidine as aneuromodulatory probe. Methods: Subjects were six depressed and six healthy women, medication free and matched for age and phase of menstrual cycle. Two PET scans were acquired at baseline and two scans at 20 and 35 min following an intravenous clonidine infusion of 1.4 mug/kg while subjects performed a sustained attention task. Results: The growth hormone response did not show a significant differencebetween groups. However, PET results revealed a difference in the right superior prefrontal cortex that was resolved as an interaction from decreasedrCBF in healthy control subjects but increased rCBF in the depressed group, which was not accounted for by differences in task performance. Conclusions: This differential effect of clonidine in the right prefrontalcortex provides in vivo evidence of noradrenergic gic dysfunction in depression, which we postulate arises from functionally impaired presynaptic alpha (2)-adrenoceptors as well as regionally "supersensitive" postsynaptic cortical alpha (2)-adrenoceptors. (C) 2001 Society of Biological Psychiatry.

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Documento generato il 26/01/20 alle ore 22:14:56