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Titolo:
Kallikrein and kinin receptor expression in inflammation and cancer
Autore:
Bhoola, K; Ramsaroop, R; Plendl, J; Cassim, B; Dlamini, Z; Naicker, S;
Indirizzi:
Technikon Natal, Fac Hlth, ZA-4000 Durban, South Africa Technikon Natal Durban South Africa ZA-4000 ZA-4000 Durban, South Africa Free Univ Berlin, Inst Vet Anat, D-14195 Berlin, Germany Free Univ BerlinBerlin Germany D-14195 et Anat, D-14195 Berlin, Germany Univ Natal, Sch Med, Dept Med, ZA-4013 Congella, South Africa Univ Natal Congella South Africa ZA-4013 ZA-4013 Congella, South Africa Univ Western Cape, Dept Biochem, ZA-7535 Bellville, Cape Town, South Africa Univ Western Cape Bellville Cape Town South Africa ZA-7535 , South Africa
Titolo Testata:
BIOLOGICAL CHEMISTRY
fascicolo: 1, volume: 382, anno: 2001,
pagine: 77 - 89
SICI:
1431-6730(200101)382:1<77:KAKREI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRADYKININ B2 RECEPTORS; RENAL-CELL CARCINOMA; TISSUE KALLIKREIN; GENE FAMILY; RHEUMATOID-ARTHRITIS; ALLOGRAFT-REJECTION; HORMONAL-REGULATION; HUMAN NEUTROPHILS; SYNOVIAL-FLUID; MESSENGER-RNA;
Keywords:
acute transplant rejection; B1 and B2 kinin receptors; glomerularnephritis; neutrophils; oesophageal and renal carcinoma; rheumatoid arthritis; tissue kallikrein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Bhoola, K Technikon Natal, Fac Hlth, POB 953, ZA-4000 Durban, South AfricaTechnikon Natal POB 953 Durban South Africa ZA-4000 outh Africa
Citazione:
K. Bhoola et al., "Kallikrein and kinin receptor expression in inflammation and cancer", BIOL CHEM, 382(1), 2001, pp. 77-89

Abstract

The kallikrein family of serine proteases has been investigated in many inflammatory disorders as molecular mapping, gene characterisation and cloning of kinin receptor genes have unfolded experimentally. In the molecular events of the inflammatory response the kallikrein cascade plays a significant role, since it is considered to initiate and maintain systemic inflammatory responses and immune-modulated disorders. A primary event is the chemotactic attraction of neutrophils which deliver the kallikrein-kinin cascade to sites of cellular injury and carcinogenic transformation of cells. The present study establishes the casual involvement of the kallikrein cascade ininfection, inflammatory joint disease, acute transplant rejection, renal glomerular diseases, angiogenesis and carcinoma. We provide strong evidence for new or enhanced expression of kinin B1 receptors in inflammation, and additionally the induction of kallikrein genes in angiogenesis and carcinoma. The results provide insights into possible roles of kallikrein inhibitorsand kinin receptor antagonists.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 23:57:34