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Titolo:
Activation of the kinin-forming cascade on the surface of endothelial cells
Autore:
Joseph, K; Ghebrehiwet, B; Kaplan, AP;
Indirizzi:
Med Univ S Carolina, Dept Med, Div Pulm & Crit Care Allergy & Clin Immunol, Charleston, SC 29425 USA Med Univ S Carolina Charleston SC USA 29425 nol, Charleston, SC 29425 USA Med Univ S Carolina, Konishi MUSC Inst Inflammat Res, Charleston, SC 29425USA Med Univ S Carolina Charleston SC USA 29425 Res, Charleston, SC 29425USA SUNY Stony Brook, Dept Med, Stony Brook, NY 11794 USA SUNY Stony Brook Stony Brook NY USA 11794 Med, Stony Brook, NY 11794 USA
Titolo Testata:
BIOLOGICAL CHEMISTRY
fascicolo: 1, volume: 382, anno: 2001,
pagine: 71 - 75
SICI:
1431-6730(200101)382:1<71:AOTKCO>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULAR-WEIGHT KININOGEN; HUMAN HAGEMAN-FACTOR; FACTOR-XII; BINDING-PROTEIN; HUMAN-PLASMA; PREKALLIKREIN; IDENTIFICATION; RECEPTOR; SITE; CYTOKERATIN-1;
Keywords:
cytokeratin 1; endothelial cells; factor XII; aC1qR; HK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Kaplan, AP Med Univ S Carolina, Dept Med, Div Pulm & Crit Care Allergy & Clin Immunol, 96 Jonathan Lucas St, Charleston, SC 29425 USA Med Univ S Carolina 96 Jonathan Lucas St Charleston SC USA 29425
Citazione:
K. Joseph et al., "Activation of the kinin-forming cascade on the surface of endothelial cells", BIOL CHEM, 382(1), 2001, pp. 71-75

Abstract

Activation of the plasma kallikrein-kinin forming cascade takes place uponincubation with human umbilical vein endothelial cells. The mechanism by which initiation occurs is uncertain. Zinc-dependent binding of plasma proteins to gC1qR, cytokeratin 1, and perhaps u-PAR is requisite for activation to take place. We demonstrate here that during a 2 hour incubation time plasma deficient in either factor XII or high molecular weight kininogen (HK) fails to activate, as compared to normal plasma, but with more prolonged incubation, factor XII-deficient plasma gradually activates while HK-deficient plasma does not. Our data support both factor XII-dependent (rapid) and factor XII-independent (slow) mechanisms; the latter may require a cell-derived protease to activate prekallikrein and the presence of zinc ions and HK.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 07:34:07