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Titolo:
Kinins and epithelial ion transport in the alimentary tract
Autore:
Cuthbert, AW;
Indirizzi:
Univ Cambridge, Addenbrookes Hosp, Dept Med, Cambridge CB1 2QQ, England Univ Cambridge Cambridge England CB1 2QQ Med, Cambridge CB1 2QQ, England
Titolo Testata:
BIOLOGICAL CHEMISTRY
fascicolo: 1, volume: 382, anno: 2001,
pagine: 57 - 60
SICI:
1431-6730(200101)382:1<57:KAEITI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHLORIDE SECRETION; COLONIC EPITHELIUM; CYCLIC-AMP; RAT COLON; BRADYKININ; MUCOSA;
Keywords:
B-1 receptors; B-2 receptors; bradykinin; lysylbradykinin; secretory diarrhoeas;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Cuthbert, AW Univ Cambridge, Addenbrookes Hosp, Dept Med, Hills Rd, Cambridge CB1 2QQ, England Univ Cambridge Hills Rd Cambridge England CB1 2QQ Q, England
Citazione:
A.W. Cuthbert, "Kinins and epithelial ion transport in the alimentary tract", BIOL CHEM, 382(1), 2001, pp. 57-60

Abstract

Kinin effects on epithelial electrogenic ion transport are reviewed, with reference to the alimentary tract. The transported ion is usually chloride,but some epithelia also transport bicarbonate. The key components of the transport system are the sodium-potassium-chloride cotransporter, Na+-K+ ATPase (both located basolaterally) and the CFTR chloride channel (located apically). Activation of K+-channels in both membranes may secondarily affect the anion transport mechanism. The types of kinin receptors that cause chloride secretion, the second messengers involved and the possible functional responsibilities of the kinin-activated secretory mechanism are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 21:26:57