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Titolo:
Signal transduction from bradykinin, angiotensin, adrenergic and muscarinic receptors to effector enzymes, including ADP-ribosyl cyclase
Autore:
Higashida, H; Yokoyama, S; Hoshi, N; Hashii, M; Egorova, A; Zhong, ZG; Noda, M; Shahidullah, M; Taketo, M; Knijnik, R; Kimura, Y; Takahashi, H; Chen, XL; Shin, Y; Zhang, JS;
Indirizzi:
Kanazawa Univ, Grad Sch Med, Dept Biophys Genet Mol Med & Bioinformat, Kanazawa, Ishikawa 9208640, Japan Kanazawa Univ Kanazawa Ishikawa Japan 9208640 wa, Ishikawa 9208640, Japan
Titolo Testata:
BIOLOGICAL CHEMISTRY
fascicolo: 1, volume: 382, anno: 2001,
pagine: 23 - 30
SICI:
1431-6730(200101)382:1<23:STFBAA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRACELLULAR CA2+ MOBILIZATION; CARDIAC RYANODINE RECEPTOR; NICOTINAMIDE-ADENINE-DINUCLEOTIDE; RAT CORTICAL ASTROCYTES; FK506 BINDING-PROTEIN; SEA-URCHIN EGGS; CADP-RIBOSE; SKELETAL-MUSCLE; CALCIUM-RELEASE; DIHYDROPYRIDINE RECEPTOR;
Keywords:
receptor-effector coupling; second messengers; signal transduction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
77
Recensione:
Indirizzi per estratti:
Indirizzo: Higashida, H Kanazawa Univ, Grad Sch Med, Dept Biophys Genet Mol Med & Bioinformat, Kanazawa, Ishikawa 9208640, Japan Kanazawa Univ Kanazawa Ishikawa Japan 9208640 9208640, Japan
Citazione:
H. Higashida et al., "Signal transduction from bradykinin, angiotensin, adrenergic and muscarinic receptors to effector enzymes, including ADP-ribosyl cyclase", BIOL CHEM, 382(1), 2001, pp. 23-30

Abstract

Muscarinic acetylcholine receptors in NG108-15 neuroblastoma x glioma cells, and beta -adrenergic or angiotensin II receptors in cortical astrocytes and/or ventricular myocytes, utilize the direct signaling pathway to ADP-ribosyl cyclase within cell membranes to produce cyclic ADP-ribose (cADPR) from beta -NAD(+), This signal cascade is analogous to the previously established transduction pathways from bradykinin receptors to phospholipase C beta and beta -adrenoceptors to adenylyl cyclase via G proteins, Upon receptorstimulation, the newly-formed cADPR may coordinately function to upregulate the release of Ca2+ from the type II ryanodine receptors as well as to facilitate Ca2+ influx through voltage-dependent Ca2+ channels, cADPR interacts with FK506, an immunosuppressant, at FKBP12.6, FK506-binding-protein, and calcineurin, or ryanodine receptors. cADPR also functions through activating calcineurin released from A-kinase anchoring protein (AKAP79), Thus, some G(q/11)-coupled receptors can control cADPR-dependent modulation in Ca2signaling.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 22:26:00