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Titolo:
The expanded human kallikrein (KLK) gene family: Genomic organisation, tissue-specific expression and potential functions
Autore:
Clements, J; Hooper, J; Dong, Y; Harvey, T;
Indirizzi:
Queensland Univ Technol, Sch Life Sci, Ctr Mol Biotechnol, Brisbane, Qld 4001, Australia Queensland Univ Technol Brisbane Qld Australia 4001 , Qld 4001, Australia
Titolo Testata:
BIOLOGICAL CHEMISTRY
fascicolo: 1, volume: 382, anno: 2001,
pagine: 5 - 14
SICI:
1431-6730(200101)382:1<5:TEHK(G>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROSTATE-SPECIFIC ANTIGEN; CORNEUM CHYMOTRYPTIC ENZYME; HUMAN GLANDULAR KALLIKREIN; ANDROGEN-REGULATED EXPRESSION; SERINE-PROTEASE GENE; MOLECULAR-CLONING; HORMONAL-REGULATION; SEQUENCE-ANALYSIS; BREAST-CANCER; CHROMOSOME 19Q13.3-Q13.4;
Keywords:
gene family; gene structure; KLK; tissue kallikrein; tissue specificity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
77
Recensione:
Indirizzi per estratti:
Indirizzo: Clements, J Queensland Univ Technol, Sch Life Sci, Ctr Mol Biotechnol, Brisbane, Qld 4001, Australia Queensland Univ Technol Brisbane Qld Australia 4001 Australia
Citazione:
J. Clements et al., "The expanded human kallikrein (KLK) gene family: Genomic organisation, tissue-specific expression and potential functions", BIOL CHEM, 382(1), 2001, pp. 5-14

Abstract

The tissue kallikreins are serine proteases encoded by highly conserved multi-gene families. The rodent kallikrein (KLK) families are particularly large, consisting of 13-26 genes clustered in one chromosomal locus. It has been recently recognised that the human KLK gene family is of a similar size(15 genes) with the identification of another 12 related genes (KLK4-KLK15) within and adjacent to the original human KLK locus (KLK1-3) on chromosome 19q13.4. The structural organisation and size of these new genes is similar to that of other KLK genes except for additional exons encoding 5' or 3'untranslated regions. Moreover, many of these genes have multiple mRNA transcripts, a trait not observed with rodent genes. Unlike all other kallikreins, the KLK4-KLK15 encoded proteases are less related (25-44%) and do not contain a conventional kallikrein loop. Clusters of genes exhibit high prostatic (KLK2-4, KLK15) or pancreatic (KLK6-13) expression, suggesting evolutionary conservation of elements conferring tissue specificity. These genes are also expressed, to varying degrees, in a wider range of tissues suggesting a functional involvement of these newer human kallikrein proteases in adiverse range of physiological processes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 02:51:15