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Titolo:
Embryonic XMab21l2 expression is required for gastrulation and subsequent neural development
Autore:
Lau, GTC; Wong, OGW; Chan, PMY; Kok, KH; Wong, RLY; Chin, KT; Lin, MCM; Kung, HF; Chow, KL;
Indirizzi:
Hong Kong Univ Sci & Technol, Dept Biol, Kowloon, Hong Kong, Peoples R China Hong Kong Univ Sci & Technol Kowloon Hong Kong Peoples R China s R China Univ Hong Kong, Inst Mol Biol, Hong Kong, Hong Kong, Peoples R China Univ Hong Kong Hong Kong Hong Kong Peoples R China Kong, Peoples R China Queen Elizabeth Hosp, Dept Pathol, Kowloon, Hong Kong, Peoples R China Queen Elizabeth Hosp Kowloon Hong Kong Peoples R China , Peoples R China
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 5, volume: 280, anno: 2001,
pagine: 1378 - 1384
SICI:
0006-291X(20010209)280:5<1378:EXEIRF>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOUBLE-STRANDED-RNA; CAENORHABDITIS-ELEGANS; C-ELEGANS; CHROMOSOMAL LOCALIZATION; GENETIC INTERFERENCE; XENOPUS-EMBRYOS; MESODERM; HOMOLOG; ZEBRAFISH; ENCODES;
Keywords:
XMab21l2; embryonic expression; gastrulation; RNAi;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Chow, KL Hong Kong Univ Sci & Technol, Dept Biol, Clear Water Bay, Kowloon, Hong Kong, Peoples R China Hong Kong Univ Sci & Technol Clear Water Bay Kowloon Hong Kong Peoples R China
Citazione:
G.T.C. Lau et al., "Embryonic XMab21l2 expression is required for gastrulation and subsequent neural development", BIOC BIOP R, 280(5), 2001, pp. 1378-1384

Abstract

Cell fate determining gene mab-21 regulates the proper establishment of neural cell fate and sensory organ identity in nematode, Mammalian homologs of mab-21 have also been implicated to play critical roles in mid-, hindbrain and craniofacial differentiation. We report here the isolation of a mab-21 homolog, XMab21l2, from Xenopus, We showed that its expression in Xenopuswas initiated at gastrulation and prominent signal was detected in neurulating embryos at the neural tube, the optic tissue, the developing midbrain,and the pharyngeal pouches. We demonstrated by RNA interference (RNAi), together with other antisense approaches, that XMab21l2 expression is required for the completion of gastrulation and subsequent neural development. (C)2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 16:14:36