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Titolo:
Orexin-A suppresses the pulsatile secretion of luteinizing hormone via beta-endorphin
Autore:
Irahara, M; Tamura, T; Matuzaki, T; Saito, S; Yasui, T; Yamano, S; Kamada, M; Aono, T;
Indirizzi:
Univ Tokushima, Sch Med, Dept Obstet & Gynecol, Tokushima 7708503, Japan Univ Tokushima Tokushima Japan 7708503 Gynecol, Tokushima 7708503, Japan
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 1, volume: 281, anno: 2001,
pagine: 232 - 236
SICI:
0006-291X(20010216)281:1<232:OSTPSO>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROPEPTIDE-Y; HYPOTHALAMIC NEUROPEPTIDES; OVARIECTOMIZED RATS; HYPOCRETIN OREXIN; PEPTIDES; NEUROENDOCRINE; SYSTEMS; PRIMATE; NEURONS; TERM;
Keywords:
orexins; LH; beta-endorphin; naloxone; pulse; GnRH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Irahara, M Univ Tokushima, Sch Med, Dept Obstet & Gynecol, 3-18-15 Kuramoto Cho, Tokushima 7708503, Japan Univ Tokushima 3-18-15 Kuramoto Cho Tokushima Japan 7708503 an
Citazione:
M. Irahara et al., "Orexin-A suppresses the pulsatile secretion of luteinizing hormone via beta-endorphin", BIOC BIOP R, 281(1), 2001, pp. 232-236

Abstract

Orexins, the novel hypothalamic neuropeptides that stimulate feeding behavior, have been shown to suppress the pulsatile secretion of LH in ovariectomized rats. However, the mechanism of this action is still not clear. We examined the effect of naloxone, a specific opioid antagonist, on the suppression of the pulsatile secretion of LH by orexins to determine whether beta -endorphin is involved in this suppressive effect. We administered orexins intracerebroventricularly and injected naloxone intravenously in ovariectomized rats, and we measured the serum LH concentration to analyze the pulsatile secretion. Administration of orexin-A significantly reduced the mean LHconcentration and the pulse frequency, but coadministration of naloxone significantly restored the mean LH concentration and the pulse frequency. Administration of orexin-B also significantly reduced the mean LH concentration and the pulse frequency, and coadministration of naloxone did not restorethem. These results indicate that orexin-A, but not orexin-B, suppresses GnRH secretion via beta -endorphin. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:20:15