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Titolo:
Protein and gene structure of a chlorocruorin chain of Eudistylia vancouverii
Autore:
Dewilde, S; Van Hauwaert, ML; Vinogradov, S; Vierstraete, A; Vanfleteren, J; Moens, L;
Indirizzi:
Univ Instelling Antwerp, Dept Biochem, Antwerp, Belgium Univ Instelling Antwerp Antwerp Belgium Dept Biochem, Antwerp, Belgium Wayne State Univ, Sch Med, Dept Biochem & Mol Biol, Detroit, MI 48201 USA Wayne State Univ Detroit MI USA 48201 m & Mol Biol, Detroit, MI 48201 USA State Univ Ghent, Dept Biol, B-9000 Ghent, Belgium State Univ Ghent Ghent Belgium B-9000 , Dept Biol, B-9000 Ghent, Belgium
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 1, volume: 281, anno: 2001,
pagine: 18 - 24
SICI:
0006-291X(20010216)281:1<18:PAGSOA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
WORM RIFTIA-PACHYPTILA; AMINO-ACID-SEQUENCES; LUMBRICUS-TERRESTRIS HEMOGLOBIN; HEXAGONAL BILAYER HEMOGLOBINS; CONSTITUENT POLYPEPTIDE-CHAIN; 3-DIMENSIONAL RECONSTRUCTION; CRYOELECTRON MICROSCOPY; GIANT HEMOGLOBIN; EXTRACELLULAR HEMOGLOBIN; QUATERNARY STRUCTURE;
Keywords:
chlorocruorin; globin chain; Eudistylia vancouverii; HLB structure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Dewilde, S Univ Instelling Antwerp, Dept Biochem, Antwerp, Belgium Univ Instelling Antwerp Antwerp Belgium em, Antwerp, Belgium
Citazione:
S. Dewilde et al., "Protein and gene structure of a chlorocruorin chain of Eudistylia vancouverii", BIOC BIOP R, 281(1), 2001, pp. 18-24

Abstract

The polychaete annelid, Eudistylia vancouverii, contains as oxygen carriera hexagonal bilayer (HBL) chlorocruorin. One of the globin chains, chain a1, has 142 amino acids (Mr 16,054.99) and its sequence deviates strongly from other nonvertebrate globin sequences. Unprecedented, it displays a Phe at the distal position E7 as well as at position B10, creating a very hydrophobic heme pocket probably responsible for the low oxygen affinity of the native molecule. Phylogenetic analysis of annelid globin chains clearly proves that globin chain al belongs to type I of globin chains having a patternof 3 cysteine residues essential for the aggregation into a HBL structure. The gene coding for globin chain al is interrupted by 2 introns at the conserved positions B12.2 and G7.0. Based on protein and gene structure it cantherefore be concluded that the globin chains of chlorocruorins are not fundamentally different from other annelid globin chains. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 07:35:05