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Titolo:
Cardiovascular and behavioural responses to psychological stress in spontaneously hypertensive rats: effect of treatment with DSP-4
Autore:
van den Buuse, M; Lambert, G; Fluttert, M; Eikelis, N;
Indirizzi:
Univ Melbourne, Behav Neurosci Lab, Mental Hlth Res Inst, Parkville, Vic 3052, Australia Univ Melbourne Parkville Vic Australia 3052 arkville, Vic 3052, Australia Baker Med Res Inst, Prahran, Vic 3181, Australia Baker Med Res Inst Prahran Vic Australia 3181 rahran, Vic 3181, Australia Leiden Univ, Leiden Amsterdam Ctr Drug Res, Leiden, Netherlands Leiden Univ Leiden Netherlands terdam Ctr Drug Res, Leiden, Netherlands
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 2, volume: 119, anno: 2001,
pagine: 131 - 142
SICI:
0166-4328(20010315)119:2<131:CABRTP>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS LOCUS COERULEUS; HEART-RATE RESPONSES; WISTAR-KYOTO RATS; BLOOD-PRESSURE; NORADRENERGIC NEURONS; BRAIN NORADRENALINE; CIRCADIAN-RHYTHMS; MENTAL STRESS; SOCIAL STRESS; NOISE STRESS;
Keywords:
behaviour; stress; blood pressure; heart rate; spontaneously hypertensive rats; noradrenaline; locus coeruleus; DSP-4;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: van den Buuse, M Univ Melbourne, Behav Neurosci Lab, Mental Hlth Res Inst,155 Oak St,Locked Bag 11, Parkville, Vic 3052, Australia Univ Melbourne 155 Oak St,Locked Bag 11 Parkville Vic Australia 3052
Citazione:
M. van den Buuse et al., "Cardiovascular and behavioural responses to psychological stress in spontaneously hypertensive rats: effect of treatment with DSP-4", BEH BRA RES, 119(2), 2001, pp. 131-142

Abstract

We used a model of psychological stress combining exposure to an open-field novel environment, radio-telemetric measurement of blood pressure and heart rate, and behavioural tracking analysis of behavioural parameters. All rats showed significant increases in blood pressure and heart rate fur the duration of open-field exposure, with spontaneously hypertensive rats (SHR) showing markedly greater presser responses and tachycardia when compared toeither Wistar-Kyoto (WKY) or Sprague-Dawley rats (SD rats). Behavioural responses in the open-field were unrelated to the magnitude of cardiovascularresponses. Open-field exposure on 4 consecutive days induced similar presser responses and tachycardia on each day. By contrast, behavioural responses were reduced from the second day of open-field exposure. Treatment of SHRand WKY rats with DSP-LF, to deplete central noradrenaline levels, did notaffect cardiovascular responses in SHR, whereas WKY rats showed a trend towards inhibition. However, in WKY rats, but not SHR, DSP-4 treatment causeda marked reduction in behavioural activity in the open-field. Tn conclusion, these data show that: (1) SHR display marked cardiovascular hyperreactivity to psychological open-field stress when compared to two normotensive rat strains; (2) unlike behavioural responses, cardiovascular stress responses do not habituate upon repeated stress exposure; and (3) noradrenergic projections from the locus coeruleus do not appear to play a major role in cardiovascular stress responses in SHR or WKY rats, although they may be involved in behavioural responses in WKY rats. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 12:59:53