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Titolo:
Stress response to surgical procedures in the submandibular region and itsinfluence on salivary secretion in mice
Autore:
Ishii, H; Nakagawa, Y;
Indirizzi:
Tsurumi Univ, Sch Dent Med, Dept Oral & Maxillofacial Surg 2, Tsurumi Ku, Yokohama, Kanagawa 2308501, Japan Tsurumi Univ Yokohama Kanagawa Japan 2308501 ama, Kanagawa 2308501, Japan
Titolo Testata:
ARCHIVES OF ORAL BIOLOGY
fascicolo: 4, volume: 46, anno: 2001,
pagine: 387 - 390
SICI:
0003-9969(200104)46:4<387:SRTSPI>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Keywords:
salivary glands; surgical stress; alpha(1)-receptor stimulation; salivation; mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
7
Recensione:
Indirizzi per estratti:
Indirizzo: Nakagawa, Y Tsurumi Univ, Sch Dent Med, Dept Oral & Maxillofacial Surg 2, Tsurumi Ku, 2-1-3 Tsurumi, Yokohama, Kanagawa 2308501, Japan Tsurumi Univ 2-1-3 Tsurumi Yokohama Kanagawa Japan 2308501 pan
Citazione:
H. Ishii e Y. Nakagawa, "Stress response to surgical procedures in the submandibular region and itsinfluence on salivary secretion in mice", ARCH ORAL B, 46(4), 2001, pp. 387-390

Abstract

Saliva stimulated by pilocarpine was collected from the mouths of adult ICR male mice after either submandibular-sublingual gland (SM-SL) exposure and SM-SL removal under pentobarbital anaesthesia. Salivary flow rates decreased and salivary protein concentrations increased after both surgical procedures. Serum cortisol was elevated after the operations. Salivary protein separation patterns on sodium dodecylsulphate-polyacrylamide gel electrophoresis (SDS-PAGE) from surgically treated animals were very similar to those from mice given an alpha (1)-adrenergic agonist (phenylephrine), but differed significantly from those given a beta -adrenergic agonist (isoproterenol). When the SM-SL was completely removed (i.e. parotid saliva), protein concentrations also dramatically increased. The SDS-PAGE protein separation pattern in the mice whose SM-SL had been removed was very similar to that in those whose SM-SL had been exposed. Hence, a surgical insult in the submandibular region in mice enhances the secretion of salivary protein, mainly inresponse to alpha (1)-adrenergic receptor stimulation in the parotid gland. This study suggests the usefulness of alpha (1)-adrencrgic receptor-stimulated parotid salivary protein as a marker of surgical insult. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 21:44:22