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Titolo:
Apomucin expression and association with Lewis antigens during gastric development
Autore:
Lopez-Ferrer, A; Barranco, C; de Bolos, C;
Indirizzi:
IMIM, Unitat Biol Cellular & Mol, Barcelona 08003, Spain IMIM Barcelona Spain 08003 t Biol Cellular & Mol, Barcelona 08003, Spain Hosp del Mar, Serv Patol, Barcelona, Spain Hosp del Mar Barcelona SpainHosp del Mar, Serv Patol, Barcelona, Spain
Titolo Testata:
APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY
fascicolo: 1, volume: 9, anno: 2001,
pagine: 42 - 48
SICI:
1062-3345(200103)9:1<42:AEAAWL>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUCIN GENE-EXPRESSION; BLOOD-GROUP ANTIGENS; MOLECULAR-CLONING; TANDEM-REPEAT; MONOCLONAL-ANTIBODY; DISTINCT PATTERNS; NORMAL TISSUE; HUMAN STOMACH; CDNA; EPITHELIUM;
Keywords:
gastric development; mucins; Lewis antigens; double-labeling immunohistochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: de Bolos, C IMIM, Unitat Biol Cellular & Mol, Dr Aiguader 80, Barcelona 08003, Spain IMIM Dr Aiguader 80 Barcelona Spain 08003 celona 08003, Spain
Citazione:
A. Lopez-Ferrer et al., "Apomucin expression and association with Lewis antigens during gastric development", APPL IMMUNO, 9(1), 2001, pp. 42-48

Abstract

In normal stomach, MUC5AC and MUC6 apomucins are associated with Lewis types 1 and 2, respectively, and this association is lost during gastric carcinogenesi The expression of gastric (MUCAC, MUC6) and intestinal (MUC2, MUC4) apomucins and Lewis antigens during gastric development, using single anddouble labeling immunohistochemistry on fetal tissues (15-41 weeks), was analyzed and related to the tumor expression patterns. Apomucin expression in other fetal tissues was also analyzed. In gastric samples, MUC2 is detected in 14 of 19 showing no correlation with fetal age, and MUC4 is not detected. MUC5AC and MUC6 are always highly detected and are coexpressed and associated with both types of Lewis antigens. These patterns change progressively with the development of the adult gastric morphology. MUC2 is detected in the small intestine, colon, and pancreas, MUC4 is expressed in the colon; MUC5AC is detected in the small intestine, and MUC6 is found in the duodenum and pancreas. The patterns of apomucin expression and association with Lewis antigens during development are complex, but then is a trend toward the establishment of the adult pattern, with the exception of MUC4, which isnot detected. These patterns found in fetal stomach indicate that alterations reported in gastric tumors do not fully recapitulate a developmental phenotype.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 18:27:08