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Titolo:
Polycationic peptides as prophylactic agents against methicillin-susceptible or methicillin-resistant Staphylococcus epidermidis vascular graft infection
Autore:
Giacometti, A; Cirioni, O; Ghiselli, R; Goffi, L; Mocchegiani, F; Riva, A; Scalise, G; Saba, V;
Indirizzi:
Univ Ancona, Inst Infect Dis & Publ Hlth, Ancona, Italy Univ Ancona Ancona Italy na, Inst Infect Dis & Publ Hlth, Ancona, Italy Univ Ancona, Natl Inst Res & Therapy Elderly, Dept Gen Surg, Ancona, ItalyUniv Ancona Ancona Italy Therapy Elderly, Dept Gen Surg, Ancona, Italy
Titolo Testata:
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
fascicolo: 12, volume: 44, anno: 2000,
pagine: 3306 - 3309
SICI:
0066-4804(200012)44:12<3306:PPAPAA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIMICROBIAL PEPTIDE; DACRON GRAFT; ANTIBIOTICS; PREVENTION; SKIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Giacometti, A Azienda Osped Umberto I, Clin Malattie Infett, Piazza Cappelli 1, I-60121 Ancona, Italy Azienda Osped Umberto I Piazza Cappelli 1 Ancona Italy I-60121
Citazione:
A. Giacometti et al., "Polycationic peptides as prophylactic agents against methicillin-susceptible or methicillin-resistant Staphylococcus epidermidis vascular graft infection", ANTIM AG CH, 44(12), 2000, pp. 3306-3309

Abstract

Several polycationic peptides isolated from animals, plants, and bacterialspecies possess a broad spectrum of antimicrobial activity. A rat model was used to investigate the efficacies of two peptides, ranalexin and buforinII, in the prevention of vascular prosthetic graft infections. The effect of peptide soaked collagen-sealed Dacron was compared to that of rifampin soaked collagen-sealed Dacron in the rat model of graft infection caused by methicillin-susceptible rifampin-susceptible Staphylococcus epidermidis andmethicillin-resistant rifampin-susceptible S. epidermidis. Graft infections were established in the back subcutaneous tissue of 240 adult male Wistarrats by implantation of 1-cm(2) Dacron prostheses, followed by topical inoculation with 2 x 10(7) CFU of S. epidermidis. The study included a controlgroup (no graft contamination), two contaminated groups that did not receive any antibiotic prophylaxis, two contaminated groups to which perioperative intraperitoneal cefazolin prophylaxis (30 mg/kg of body weight) was administered, six contaminated groups that received a peptide- or rifampin-soaked graft, and six contaminated groups that received a peptide- or rifampin-soaked graft and perioperative intraperitoneal cefazolin prophylaxis (30 mg/kg). The grafts were sterilely removed 7 days after implantation, and the infection was evaluated by using sonication and quantitative agar culture. Overall, the efficacies of the polycationic peptides against the methicillin susceptible and methicillin resistant strains were not significantly different from that of rifampin. Nevertheless, the combinations of ranalexin- and buforin II-coated grafts with cefazolin treatment demonstrated efficacies significantly higher than that of the combination of rifampin coated grafts and cefazolin treatment against the methicillin resistant strain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/21 alle ore 15:53:57