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Titolo:
High-level fluoroquinolone-resistant clinical isolates of Escherichia colioverproduce multidrug efflux protein AcrA
Autore:
Mazzariol, A; Tokue, Y; Kanegawa, TM; Cornaglia, G; Nikaido, H;
Indirizzi:
Univ Calif Berkeley, Dept Cell & Mol Biol, Berkeley, CA 94720 USA Univ Calif Berkeley Berkeley CA USA 94720 ol Biol, Berkeley, CA 94720 USA Univ Verona, Dept Pathol, Microbiol Sect, I-37100 Verona, Italy Univ Verona Verona Italy I-37100 , Microbiol Sect, I-37100 Verona, Italy
Titolo Testata:
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
fascicolo: 12, volume: 44, anno: 2000,
pagine: 3441 - 3443
SICI:
0066-4804(200012)44:12<3441:HFCIOE>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTIPLE-ANTIBIOTIC-RESISTANCE; TOPOISOMERASE-IV; MAR MUTANTS; MUTATIONS; PARC; PUMP; PERIPLASM; PLAYS; GENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Nikaido, H Univ Calif Berkeley, Dept Cell & Mol Biol, Room 229 Stanley Hall, Berkeley, CA 94720 USA Univ Calif Berkeley Room 229 Stanley Hall Berkeley CA USA 94720
Citazione:
A. Mazzariol et al., "High-level fluoroquinolone-resistant clinical isolates of Escherichia colioverproduce multidrug efflux protein AcrA", ANTIM AG CH, 44(12), 2000, pp. 3441-3443

Abstract

Immunoblotting with antibody against AcrA, an obligatory component of the AcrAB multidrug efflux system, showed that this protein was overexpressed by greater than or equal to 170% in 9 of 10 clinical isolates of Esherichia coli with high-level ciprofloxacin resistance (MICs, greater than or equal to 32 mug/ml) but not in any of the 15 isolates for which the MIC was less than or equal to1 mug/ml.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 15:58:15