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Titolo:
Indolent T-lymphoblastic proliferation - Report of a case with an 11-year history and association with myasthenia gravis
Autore:
Strauchen, JA;
Indirizzi:
Mt Sinai Sch Med, Dept Pathol, New York, NY 10029 USA Mt Sinai Sch Med New York NY USA 10029 ept Pathol, New York, NY 10029 USA
Titolo Testata:
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
fascicolo: 3, volume: 25, anno: 2001,
pagine: 411 - 415
SICI:
0147-5185(200103)25:3<411:ITP-RO>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
LYMPHOMA;
Keywords:
myasthenia gravis; T-lymphoblastic lymphoma; oropharynx;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Strauchen, JA Mt Sinai Sch Med, Dept Pathol, Box 1194,1 gustave Levy Pl, New York, NY 10029 USA Mt Sinai Sch Med Box 1194,1 gustave Levy Pl New York NY USA 10029
Citazione:
J.A. Strauchen, "Indolent T-lymphoblastic proliferation - Report of a case with an 11-year history and association with myasthenia gravis", AM J SURG P, 25(3), 2001, pp. 411-415

Abstract

T-lymphoblastic lymphoma is a high-grade malignant lymphoma with frequent occurrence in young males, mediastinal involvement, and systemic dissemination. Indolent T-lymphoblastic proliferations have rarely been recognized. In the present case, we report on an indolent T-lymphoblastic proliferation involving the oropharynx in a patient with myasthenia gravis with multiple local recurrences over an 11-year period without evidence of systemic dissemination. The T-lymphoblasts were consistently positive for terminal deoxynucleotidyl transferase (TdT), CD1, CD3, CD4, and CD8, corresponding to an intermediate thymocyte stage of differentiation. No cytokeratin-positive thymic epithelial cells were identified, ruling out an ectopic thymus or thymoma. T-receptor gene rearrangement studies by Southern blot revealed no monoclonal CT-beta rearrangement. Indolent T-lymphoblastic proliferations of undetermined clonality may rarely occur; predilection for involvement of oropharynx and possible association with myasthenia gravis are suggested.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 15:57:30