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Titolo:
Primary cutaneous large B-cell lymphoma - The relation between morphology,clinical presentation, immunohistochemical markers, and survival
Autore:
Fernandez-Vazquez, A; Rodriguez-Peralto, JL; Martinez, MA; Platon, EM; Algara, P; Camacho, FI; Lopez-Rios, F; Zarco, C; Sanchez-Yus, E; Fresno, MF; Barthe, L; Aliaga, A; Fraga, M; Forteza, J; Oliva, H; Piris, MA;
Indirizzi:
Ctr Nacl Invest Oncol, Programa Patol Mol, Madrid 28220, Spain Ctr Nacl Invest Oncol Madrid Spain 28220 Patol Mol, Madrid 28220, Spain Hosp Virgen Salud, Dept Pathol, Toledo, Spain Hosp Virgen Salud Toledo Spain Virgen Salud, Dept Pathol, Toledo, Spain Hosp Virgen Salud, Dept Dermatol, Toledo, Spain Hosp Virgen Salud ToledoSpain rgen Salud, Dept Dermatol, Toledo, Spain Hosp Virgen Salud, Dept Stat, Toledo, Spain Hosp Virgen Salud Toledo Spain p Virgen Salud, Dept Stat, Toledo, Spain Hosp 12 Octubre, Fdn Jimenez Diaz, Hosp Clin, E-28041 Madrid, Spain Hosp 12 Octubre Madrid Spain E-28041 z, Hosp Clin, E-28041 Madrid, Spain REsidencia Ntra Sra Covadonga, Oviedo, Spain REsidencia Ntra Sra Covadonga Oviedo Spain Sra Covadonga, Oviedo, Spain Gen Hosp, Valencia, Spain Gen Hosp Valencia SpainGen Hosp, Valencia, Spain Hosp Gen Galica, Santiago De Compostela, Spain Hosp Gen Galica Santiago De Compostela Spain tiago De Compostela, Spain
Titolo Testata:
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
fascicolo: 3, volume: 25, anno: 2001,
pagine: 307 - 315
SICI:
0147-5185(200103)25:3<307:PCLBL->2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
BCL-2 PROTEIN EXPRESSION; TREATMENT-OF-CANCER; EORTC CLASSIFICATION; FOLLICULAR LYMPHOMA; FEATURES; ORIGIN; POLYCHEMOTHERAPY; TRANSLOCATION; PROGNOSIS; PROPOSAL;
Keywords:
primary cutaneous large B-cell lymphoma; immunohistochemistry; failure-free survival; p53; bcl2; MIB1; bcl6; CD10;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Piris, MA Ctr Nacl Invest Oncol, Programa Patol Mol, Ctra Majadahonda Pozuelo,Km 2, Madrid 28220, Spain Ctr Nacl Invest Oncol Ctra Majadahonda Pozuelo,Km 2 Madrid Spain 28220
Citazione:
A. Fernandez-Vazquez et al., "Primary cutaneous large B-cell lymphoma - The relation between morphology,clinical presentation, immunohistochemical markers, and survival", AM J SURG P, 25(3), 2001, pp. 307-315

Abstract

The histogenesis, morphology, immunophenotype, and clinical behavior of cutaneous large B-cell lymphomas (CLBCL) are largely a matter of controversy. We performed an investigation to determine whether CLBCL have features that differentiate them from other large B-cell lymphomas and whether CLBCL isitself a heterogeneous group. To this end, we reviewed the main characteristics of a series of 32 cases of LBCL found in the skin. We reviewed the clinical findings and paraffin sections of the tumors from these 32 patients. The immunohistochemical study performed included p53, MIB1, Bcl2, Bcl6, and CD10 markers. We carried out statistical analysis of these data (univariate and multivariate), seeking an association between the features of the tumors and clinical outcome, as defined by failure-free survival time. Only one patient died as a consequence of the lymphoma. Nevertheless, the accumulated probability of survival without failure at 48 months was 0.46. The number, type, and localization of the lesions were not associated with variations in either survival or failure-free survival. The expression of p53 was negative in this group of CLBCL, whereas Bcl-2 expression or localization in the lower leg did not relate to any other significant feature. Histologicexamination of the cases disclosed three different groups: Grade III follicular lymphomas (FLs), monomorphous large B-cell lymphomas (LBCL type L), and LBCL with an admired component of small B-lymphocytes (LBCL type II). Grade III FL (11 cases) tended to be found in the head and neck and showed CD10 expression in a majority of cases. A higher probability of lymph node relapses was associated with cases located in the head and neck and with CD10 tumors. Cutaneous large B-cell lymphomas are indolent tumors, but follow an insidious course. Our data support the interpretation that CLBCL is a heterogeneous condition; comprises some LBCL derived from CD10+ germinal center cells which manifests more frequently as tumors in the head and neck region, with an increased probability of relapse in lymph nodes [1] and has some distinctive morphologic features. The existence of a component of small B-cells within the other CLBCL could lend support to the theory that some of these tumors, more than arise de novo, may have originated in preexistentsmall B-cell lymphomas, but no firm evidence of this is provided in this study.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 10:44:23