Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Exaggerated neurogenic inflammation and substance p receptor upregulation in RSV-infected weanling rats
Autore:
King, KA; Hu, CP; Rodriguez, MM; Romaguera, R; Jiang, XB; Piedimonte, G;
Indirizzi:
Univ Miami, Sch Med, Pediat Pulm & Cyst Fibrosis Ctr, Dept Pediat, Miami, FL 33136 USA Univ Miami Miami FL USA 33136 rosis Ctr, Dept Pediat, Miami, FL 33136 USA Univ Miami, Sch Med, Dept Med, Miami, FL 33136 USA Univ Miami Miami FL USA 33136 ami, Sch Med, Dept Med, Miami, FL 33136 USA Univ Miami, Sch Med, Dept Mol & Cellular Pharmacol, Miami, FL 33136 USA Univ Miami Miami FL USA 33136 l & Cellular Pharmacol, Miami, FL 33136 USA Univ Miami, Sch Med, Dept Pathol, Miami, FL 33136 USA Univ Miami Miami FLUSA 33136 , Sch Med, Dept Pathol, Miami, FL 33136 USA
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
fascicolo: 2, volume: 24, anno: 2001,
pagine: 101 - 107
SICI:
1044-1549(200102)24:2<101:ENIASP>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY SYNCYTIAL VIRUS; HUMANIZED MONOCLONAL-ANTIBODY; NEUROPEPTIDES; CAPSAICIN; DISEASE; AIRWAYS; TISSUE; TRACT; CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Piedimonte, G Univ Miami, Sch Med, Pediat Pulm & Cyst Fibrosis Ctr, Dept Pediat, 1601 NW12th Ave, Miami, FL 33136 USA Univ Miami 1601 NW 12th Ave Miami FL USA 33136 FL 33136 USA
Citazione:
K.A. King et al., "Exaggerated neurogenic inflammation and substance p receptor upregulation in RSV-infected weanling rats", AM J RESP C, 24(2), 2001, pp. 101-107

Abstract

Respiratory syncytial virus (RSV) infection in adult rats causes exaggerated inflammation after sensory nerve stimulation in the extrapulmonary, but not in the intrapulmonary airways. The goal of this study was to analyze neurogenic inflammation in weanling F-344 rats infected with RSV 18 +/- 2 d after birth. Five days after RSV inoculation, the extravasation of Evens blue-labeled albumin after nerve stimulation was significantly greater in the intrapulmonary airways of RSV-infected weanling rats than in pathogen-free control rats. In contrast, no difference was found in the extrapulmonary airways. The level of messenger RNA (mRNA) encoding the substance P (SP) receptor (neurokinin 1 [NK1]) increased fourfold in RSV-infected lungs, whereasmRNA encoding the VIPR1 receptor for the antiinflammatory vasoactive intestinal peptide (VIP) increased to a much lesser degree. mRNAs encoding the other neurokinin (NK2) and VIP (VIPR2) receptors were not affected by the virus. Selective inhibition of the NK1 receptor abolished neurogenic inflammation in RSV-infected intrapulmonary airways. Also, neurogenic inflammation and NK1 receptor upregulation in infected lungs were inhibited by prophylaxis with a monoclonal antibody against RSV. These data suggest that RSV lower respiratory tract infection makes the intrapulmonary airways of young rats abnormally susceptible to the proinflammatory effects of SP by selectively upregulating the expression of NK1 receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 10:34:58