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Titolo:
Serum triglycerides and risk of coronary heart disease among Japanese men and women
Autore:
Iso, H; Naito, Y; Sato, S; Kitamura, A; Okamura, T; Sankai, T; Shimamoto, T; Lida, M; Komachi, Y;
Indirizzi:
Univ Tsukuba, Inst Community Med, Tsukuba, Ibaraki 305, Japan Univ Tsukuba Tsukuba Ibaraki Japan 305 y Med, Tsukuba, Ibaraki 305, Japan Osaka Med Ctr Canc & Cardiovasc Dis, Dept Epidemiol & Mass Examinat Cardiovasc Dis, Higashinari Ku, Osaka, Japan Osaka Med Ctr Canc & Cardiovasc DisOsaka Japan hinari Ku, Osaka, Japan Osaka Prefectural Inst Publ Hlth, Higashinari Ku, Osaka 537, Japan Osaka Prefectural Inst Publ Hlth Osaka Japan 537 ri Ku, Osaka 537, Japan
Titolo Testata:
AMERICAN JOURNAL OF EPIDEMIOLOGY
fascicolo: 5, volume: 153, anno: 2001,
pagine: 490 - 499
SICI:
0002-9262(20010301)153:5<490:STAROC>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-DENSITY-LIPOPROTEIN; MYOCARDIAL-INFARCTION; ARTERY DISEASE; PLASMA TRIGLYCERIDE; CHOLESTEROL CONCENTRATIONS; CARDIOVASCULAR-DISEASE; HDL CHOLESTEROL; FOLLOW-UP; MORTALITY; PREDICTORS;
Keywords:
cholesterol; coronary disease; incidence; triglycerides;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Iso, H Univ Tsukuba, Inst Community Med, 1-1-1 Tennodai, Tsukuba, Ibaraki 305, Japan Univ Tsukuba 1-1-1 Tennodai Tsukuba Ibaraki Japan 305 ki 305, Japan
Citazione:
H. Iso et al., "Serum triglycerides and risk of coronary heart disease among Japanese men and women", AM J EPIDEM, 153(5), 2001, pp. 490-499

Abstract

To examine the relation of triglycerides with coronary heart disease amongpopulations with low mean total cholesterol, the authors conducted a 15.5-year prospective study ending in 1997 of 11,068 Japanese aged 40-69 years (4,452 men and 6,616 women with mean total cholesterol = 4.73 mmol/liter and5.03 mmol/liter, respectively), initially free of coronary heart disease or stroke. There were 236 coronary heart disease events comprising 133 myocardial infarctions, 68 angina pectoris events, and 44 sudden cardiac deaths. The coronary heart disease incidence was greater in a dose-response manneracross increasing quartiles of nonfasting triglycerides for both sexes. The multivariate relative risk of coronary heart disease adjusting for coronary risk factors and time since last meal associated with a 1-mmol/liter increase in triglycerides was 1.29 (95% confidence interval (CI): 1.09, 1.53; p = 0.004) for men and 1.42 (95% Cl: 1.15, 1.75; p = 0.001) for women. The trend was similar for myocardial infarction, angina pectoris, and sudden cardiac death. The relation of triglycerides with coronary heart disease was not influenced materially by total cholesterol levels or, in a subsample analysis (51% of total sample), by high density lipoprotein cholesterol levels. Nonfasting serum triglycerides predict the incidence of coronary heart disease among Japanese men and women who possess low mean values of total cholesterol. Further adjustment for high density lipoprotein cholesterol suggests an independent role of triglycerides on the coronary heart disease risk.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 16:24:31