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Titolo:
Associations of blood lead, dimercaptosuccinic acid-chelatable lead, and tibia lead with neurobehavioral test scores in South Korean lead workers
Autore:
Schwartz, BS; Lee, BK; Lee, GS; Stewart, WF; Lee, SS; Hwang, KY; Ahn, KD; Kim, YB; Bolla, KI; Simon, D; Parsons, PJ; Todd, AC;
Indirizzi:
Johns Hopkins Univ, Sch Hyg & Publ Hlth, Div Occupat & Environm Hlth, DeptEnvironm Hlth Sci, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MDUSA 21205 th Sci, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 pt Med, Baltimore, MD 21205 USA Johns Hopkins Univ, Sch Hyg & Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 demiol, Baltimore, MD 21205 USA Soonchunhyang Univ, Inst Ind Med, Chonan, South Korea Soonchunhyang Univ Chonan South Korea Inst Ind Med, Chonan, South Korea Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 Neurol, Baltimore, MD 21205 USA New York State Dept Hlth, Wadsworth Ctr, Lead Poisoning Trace Elements Lab, Albany, NY USA New York State Dept Hlth Albany NY USA race Elements Lab, Albany, NY USA Mt Sinai Med Ctr, Dept Community & Prevent Med, New York, NY 10029 USA Mt Sinai Med Ctr New York NY USA 10029 revent Med, New York, NY 10029 USA
Titolo Testata:
AMERICAN JOURNAL OF EPIDEMIOLOGY
fascicolo: 5, volume: 153, anno: 2001,
pagine: 453 - 464
SICI:
0002-9262(20010301)153:5<453:AOBLDA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
X-RAY-FLUORESCENCE; INORGANIC LEAD; EXPOSURE; PERFORMANCE; BONE; STORAGE; ADULTS;
Keywords:
cross-sectional studies; lead; lead poisoning, nervous system, adult; nervous system; neurobehavioral manifestations; neurologic manifestations; occupational exposure; spectrometry, x-ray emission;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Schwartz, BS Johns Hopkins Univ, Sch Hyg & Publ Hlth, Div Occupat & Environm Hlth, DeptEnvironm Hlth Sci, 615 N Wolfe St,Room 7041, Baltimore, MD 21205 USA Johns Hopkins Univ 615 N Wolfe St,Room 7041 Baltimore MD USA 21205
Citazione:
B.S. Schwartz et al., "Associations of blood lead, dimercaptosuccinic acid-chelatable lead, and tibia lead with neurobehavioral test scores in South Korean lead workers", AM J EPIDEM, 153(5), 2001, pp. 453-464

Abstract

The authors performed a cross-sectional study to evaluate associations between blood lead, tibia lead, and dimercaptosuccinic acid (DMSA)-chelatable lead and measures of neurobehavioral and peripheral nervous system functionamong 803 lead-exposed workers and 135 unexposed controls in South Korea. The workers and controls were enrolled in the study between October 1997 and August 1999. Central nervous system function was assessed with a modifiedversion of the World Health Organization Neurobehavioral Core Test Battery. Peripheral nervous system function was assessed by measuring pinch and grip strength and peripheral vibration thresholds. After adjustment for covariates, the signs of the beta coefficients for blood lead were negative for 16 of the 19 tests and blood lead was a significant predictor of worse performance on eight tests. On average, for the eight tests that were significantly associated with blood lead levels, an increase in blood lead of 5 mug/dl was equivalent to an increase of 1.05 years in age. in contrast, after adjustment for covariates, tibia lead level was not associated with neurobehavioral test scores. Associations with DMSA-chelatable lead were similar tothose for blood lead. In these currently exposed workers, blood lead was abetter predictor of neurobehavioral performance than was tibia or DMSA-chelatable lead, mainly in the domains of executive abilities, manual dexterity, and peripheral motor strength.

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Documento generato il 06/07/20 alle ore 05:48:50