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Titolo:
Determinants of plasma total homocysteine concentration in the Framingham Offspring cohort
Autore:
Jacques, PF; Bostom, AG; Wilson, PWF; Rich, S; Rosenberg, IH; Selhub, J;
Indirizzi:
Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, Boston, MA 02111 USATufts Univ Boston MA USA 02111 n Nutr Res Ctr Aging, Boston, MA 02111 USA Brown Univ, Mem Hosp Rhode Isl, Div Gen Internal Med, Pawtucket, RI 02860 USA Brown Univ Pawtucket RI USA 02860 n Internal Med, Pawtucket, RI 02860 USA Boston Univ, Sch Med, Framingham Heart Study, Framingham, MA USA Boston Univ Framingham MA USA Framingham Heart Study, Framingham, MA USA
Titolo Testata:
AMERICAN JOURNAL OF CLINICAL NUTRITION
fascicolo: 3, volume: 73, anno: 2001,
pagine: 613 - 621
SICI:
0002-9165(200103)73:3<613:DOPTHC>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUTRITION EXAMINATION SURVEY; 3RD NATIONAL-HEALTH; WOMEN AGED 65; FOLIC-ACID; HORDALAND HOMOCYSTEINE; SERUM HOMOCYSTEINE; METHYLENETETRAHYDROFOLATE REDUCTASE; REPRESENTATIVE SAMPLE; MICROBIOLOGICAL ASSAY; LACTOBACILLUS-CASEI;
Keywords:
homocysteine; diet; folate; vitamin B-12; creatinine; smoking; caffeine; alcohol consumption; hypertension; epidemiology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Jacques, PF Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, 711 Washington St, Boston, MA 02111 USA Tufts Univ 711 Washington St Boston MA USA 02111 MA 02111 USA
Citazione:
P.F. Jacques et al., "Determinants of plasma total homocysteine concentration in the Framingham Offspring cohort", AM J CLIN N, 73(3), 2001, pp. 613-621

Abstract

Background: Established determinants of fasting total homocysteine (tHcy) concentration include folate and vitamin B-12 status, serum creatinine concentration, and renal function. Objective: Our objective was to examine the relation between known and suspected determinants of fasting plasma tHcy in a population-based cohort. Design: We examined the relations between fasting plasma tHcy concentrations and nutritional and other health factors in 1960 men and women, aged 28-82 y, from the fifth examination cycle of the Framingham Offspring Study between 1991 and 1994, before the implementation of folic acid fortification. Results: Geometric mean tHcy was 11% higher in men than in women and 23% higher in persons aged greater than or equal to 65 y than in persons aged <45 y (P < 0.001). tHcy was associated with plasma folate, vitamin B-12, and pyridoxal phosphate (P for trend < 0.001). Dietary folate, vitamin B-6, andriboflavin were associated with tHcy among non-supplement users (P for trend < 0.01). The tHcy concentrations of persons who used vitamin B supplements were 18% lower than those of persons who did not (P < 0.001). tHcy was positively associated with alcohol intake (P for trend = 0.004), caffeine intake (P for trend < 0.001), serum creatinine (P for trend < 0.001), number of cigarettes smoked (P for trend < 0.001), and antihypertensive medicationuse (P < 0.001). Conclusions: Our study confirmed, in a population-based setting, the importance of the known determinants of fasting tHcy and suggested that other dietary and lifestyle factors, including vitamin B-6, riboflavin, alcohol, and caffeine intakes as well as smoking and hypertension, influence circulating tHcy concentrations.

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Documento generato il 04/04/20 alle ore 20:41:57