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Titolo:
Activation mechanism of brain microglia in patients with diffuse neurofibrillary tangles with calcification: A comparison with Alzheimer disease
Autore:
Imamura, K; Sawada, M; Ozaki, T; Naito, H; Iwata, T; Ishihara, R; Takeuchi, T; Shibayama, G;
Indirizzi:
Okazaki City Hosp, Dept Neurol, Okazaki, Aichi 4448553, Japan Okazaki CityHosp Okazaki Aichi Japan 4448553 azaki, Aichi 4448553, Japan Fujita Hlth Univ, Inst Comprehens Med Sci, Aichi, Japan Fujita Hlth Univ Aichi Japan niv, Inst Comprehens Med Sci, Aichi, Japan Japan Sci & Technol Corp, PRESTO, Aichi, Japan Japan Sci & Technol Corp Aichi Japan Technol Corp, PRESTO, Aichi, Japan Fujita Hlth Univ, Sch Med, Dept Psychiat, Aichi, Japan Fujita Hlth Univ Aichi Japan Univ, Sch Med, Dept Psychiat, Aichi, Japan Nagoya Univ, Sch Med, Dept Psychiat, Nagoya, Aichi 466, Japan Nagoya UnivNagoya Aichi Japan 466 ept Psychiat, Nagoya, Aichi 466, Japan Shiroyama Hosp, Chikusa Ku, Nagoya, Aichi, Japan Shiroyama Hosp Nagoya Aichi Japan Hosp, Chikusa Ku, Nagoya, Aichi, Japan
Titolo Testata:
ALZHEIMER DISEASE & ASSOCIATED DISORDERS
fascicolo: 1, volume: 15, anno: 2001,
pagine: 45 - 50
SICI:
0893-0341(200101/03)15:1<45:AMOBMI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; REACTIVE MICROGLIA; HLA-DR; PRESENILE-DEMENTIA; AMYLOID DEPOSITS; SENILE DEMENTIA; ANTIGENS; CELLS; IMMUNOREACTIVITY; PARKINSONISM;
Keywords:
diffuse neurofibrillary tangles with calcification; Alzheimer disease; microglia; HLA-DR; neurofibrillary tangles;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Imamura, K Okazaki City Hosp, Dept Neurol, Kouryuji Cho, Okazaki, Aichi 4448553, Japan Okazaki City Hosp Kouryuji Cho Okazaki Aichi Japan 4448553 apan
Citazione:
K. Imamura et al., "Activation mechanism of brain microglia in patients with diffuse neurofibrillary tangles with calcification: A comparison with Alzheimer disease", ALZ DIS A D, 15(1), 2001, pp. 45-50

Abstract

Diffuse neurofibrillary tangles with calcification (DNTC) is an atypical dementia and is characterized pathologically by diffuse neurofibrillary tangles (NFTs) without senile plaques (SPs). In this study, we investigated thedistribution of human leukocyte antigen (HLA)-DR-positive activated microglia in postmortem brain tissue of six patients with DNTC and six patients with Alzheimer disease (AD). HLA-DR-positive activated microglia were observed to associate with SPs in AD. In the DNTC brain, which lacks SPs, HLA-DR-positive microglia were mainly accumulated around weakly tan-positive NFTs,which were also positive for anti-amyloid-P and anti-C3d antibodies. The results of this study suggest that the complement pathway is also activated in the DNTC brain and that immune and inflammatory responses, including microglia activation, may occur around extracellular NFTs in DNTC patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/09/19 alle ore 22:41:28