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Titolo:
Patent ductus venosus does not lead to alimentary galactosaemia in preterminfants
Autore:
Fugelseth, D; Guthenberg, C; Hagenfeldt, L; Liestol, K; Hallerud, M; Lindemann, R;
Indirizzi:
Ulleval Univ Hosp, Dept Paediat, NO-0407 Oslo, Norway Ulleval Univ Hosp Oslo Norway NO-0407 Dept Paediat, NO-0407 Oslo, Norway Karolinska Inst, Huddinge Hosp, CMMS, S-10401 Stockholm, Sweden KarolinskaInst Stockholm Sweden S-10401 CMMS, S-10401 Stockholm, Sweden Univ Oslo, Dept Informat, N-0316 Oslo, Norway Univ Oslo Oslo Norway N-0316 iv Oslo, Dept Informat, N-0316 Oslo, Norway
Titolo Testata:
ACTA PAEDIATRICA
fascicolo: 2, volume: 90, anno: 2001,
pagine: 192 - 195
SICI:
0803-5253(200102)90:2<192:PDVDNL>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-FLOW VELOCITY; NECROTIZING ENTEROCOLITIS; PREMATURE-INFANTS; HUMAN-MILK; CIRCULATORY ADAPTATION; BREAST-MILK; GALACTOSEMIA; GROWTH;
Keywords:
breast milk; ductus venosus; echocardiography; galactosaemia; portal-venous shunt; preterm infants;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Fugelseth, D Ulleval Univ Hosp, Dept Paediat, NO-0407 Oslo, Norway UllevalUniv Hosp Oslo Norway NO-0407 NO-0407 Oslo, Norway
Citazione:
D. Fugelseth et al., "Patent ductus venosus does not lead to alimentary galactosaemia in preterminfants", ACT PAEDIAT, 90(2), 2001, pp. 192-195

Abstract

The aim of this study was to investigate if an open ductus venosus representing a portal-caval shunt can lead to transient "alimentary galactosaemia"in preterm infants fed human breast milk. Twenty-six preterm infants (28-34 wk of gestational age) with open ductus venosus were included. Capillary blood samples for measurement of galactose and glucose were collected before, 30 and 50 min after a meal with breast milk (range 12-23 mL/kg). Ultrasound studies of the blood flow in the ductus venosus, truncus coeliacus, superior mesenteric artery and left hepatic vein were performed before and 30 min after the meal. There was a significant rise in blood glucose after 30 and 50 min, indicating a sufficient lactose load. Galactose, however, was either not detectable or was just above the detectable limit (0.1-0.4 mmol/L), with no changes after the meal. An increased flow velocity was found in the ductus venosus and superior mesenteric artery after 30 min (p less thanor equal to 0.001) indicating increased entero-hepatic and portal-caval shunting. Conclusion: A patent ductus venosus does not lead to a significant hypergalactosaemia in preterm infants fed human breast milk. Thus, in respect to breast-milk feeding, this is regarded safe in healthy preterm infants even with an open ductus venosus. The increased portal-caval shunting may, however, influence the hepatic metabolism of other enterally absorbed substances.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 08:52:34