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Titolo:
The vestibular evoked response to linear, alternating, acceleration pulseswithout acoustic masking as a parameter of vestibular function
Autore:
Oei, MLYM; Segenhout, JM; Wit, HP; Albers, FWJ;
Indirizzi:
Univ Groningen Hosp, Dept Otorhinolaryngol Head & Neck Surg, NL-9700 RB Groningen, Netherlands Univ Groningen Hosp Groningen Netherlands NL-9700 RBningen, Netherlands
Titolo Testata:
ACTA OTO-LARYNGOLOGICA
fascicolo: 1, volume: 121, anno: 2001,
pagine: 62 - 67
SICI:
0001-6489(200101)121:1<62:TVERTL>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
POTENTIALS VSEPS; IMPULSES;
Keywords:
evoked potentials; guinea pig; linear acceleration; short latency; vestibular; vestibule physiology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Oei, MLYM Univ Groningen Hosp, Dept Otorhinolaryngol, POB 30-001, NL-9700 RB Groningen, Netherlands Univ Groningen Hosp POB 30-001 Groningen Netherlands NL-9700 RB
Citazione:
M.L.Y.M. Oei et al., "The vestibular evoked response to linear, alternating, acceleration pulseswithout acoustic masking as a parameter of vestibular function", ACT OTO-LAR, 121(1), 2001, pp. 62-67

Abstract

In this study, short latency vestibular evoked potentials (VsEPs) were recorded in five guinea pigs in response to alternating linear acceleration pulses with and without acoustic masking. A steel bolt was implanted in the skull and coupled to a shaker. Linear acceleration pulses (n = 400) in upward, downward or alternating directions were given, with a peak acceleration of 4g after 0.5 msec. Tests were repeated with acoustic masking, after modiolus destruction and after application of KCl in the vestibule. Stimuli of the vestibular nerve were recorded with a platinum electrode in the bony facial nerve canal in the bulla. Unilateral linear acceleration showed a shallow plateau at 0.5 msec, which disappeared with alternating acceleration impulses and after modiolus destruction. Therefore all further tests were done with alternating impulses. After a latency time of 0.8 msec a multiwave response was seen, with a first positive peak P1 at 1.16 ms. These were followed by other positive and negative peaks (N1, P2, N2, P3, N3). With the elimination of cochlear influences by using acoustic masking, P1 remained stable, while subsequent peaks were altered or eliminated. After modiolus destruction, the P1 peak remained, although with a smaller amplitude due to vestibular damage. After application of a saturated KCl solution in the vestibule all responses, including P1, disappeared, thus confirming the vestibular origin of these responses. We conclude that the onset latency of the VsEPand the peak latency and level of the first positive peak P1 in response to alternating linear acceleration pulses without acoustic masking, measuredin the facial canal, are good and stable parameters of vestibular functionin guinea pigs.

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Documento generato il 27/01/21 alle ore 02:33:53